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mRNP regulated by BTG4 [cytosol]
Stable Identifier
R-HSA-9817647
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
M-decay: degradation of maternal mRNAs by maternally stored factors (Homo sapiens)
BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP (Homo sapiens)
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
mRNP regulated by BTG4 [cytosol] (Homo sapiens)
General
mRNA's that are ready for translation have a circular structure caused by interaction between PABP bound to the 3' poly(A) tail and the eIF4E-eIF4G-PAIP complex bound to the 7-methylguanosine cap. The interaction between poly(A)-PABP and the eIF4G-eIF4E complex stimulates affinity of eIF4E for the cap and improves translation.
Participants
components
eIF4A [cytosol]
(Homo sapiens)
EIF4B [cytosol]
(Homo sapiens)
EIF4E [cytosol]
(Homo sapiens)
EIF4G1 [cytosol]
(Homo sapiens)
mRNA regulated by BTG4 [cytosol]
(Homo sapiens)
PABPC1 [cytosol]
(Homo sapiens)
PAIP1 [cytosol]
(Homo sapiens)
Participates
as an input of
BTG4 binds CNOT7 of the CCR4-NOT complex, PABPN1L, and eIF4E of the mRNP (Homo sapiens)
as a component of
CCR4-NOT:BTG4:PABPN1L:mRNP [cytosol] (Homo sapiens)
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