Reactome | pabpc1B [cytosol]

pabpc1B [cytosol]

Stable Identifier

R-DDI-156803

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

PABPC1, Q1ZXC2

Locations in the PathwayBrowser

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Metabolism of RNA (Dictyostelium discoideum)

- Nonsense-Mediated Decay (NMD) (Dictyostelium discoideum)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Dictyostelium discoideum)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Dictyostelium discoideum)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Dictyostelium discoideum)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)
- Regulation of mRNA stability by proteins that bind AU-rich elements (Dictyostelium discoideum)
  - AUF1 (hnRNP D0) binds and destabilizes mRNA (Dictyostelium discoideum)
    - AUF1 (hnRNP D0) is ubiquitinylated (Dictyostelium discoideum)
      - AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)

Metabolism of proteins (Dictyostelium discoideum)

- Translation (Dictyostelium discoideum)
  - Eukaryotic Translation Initiation (Dictyostelium discoideum)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Dictyostelium discoideum)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Dictyostelium discoideum)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Dictyostelium discoideum)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Dictyostelium discoideum)
        
        pabpc1B [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q1ZXC2

Gene Names

pabpc1B

Reference Genes

BioGPS Gene:8627795 pabpc1B

dictyBase:DDB_G0290745

ENSEMBL:DDB_G0290745

KEGG Gene (Dictyostelium discoideum):DDB_G0290745 pabpc1B

Monarch:8627795 pabpc1B

NCBI Gene:8627795 pabpc1B

Reference Transcript

RefSeq:XM_001134510.1 pabpc1B

Participates

as a component of

Inferred From

PABPC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_001134510.1

PRO

Q1ZXC2