PARN deadenylates mRNA

Stable Identifier
Reaction [transition]
Homo sapiens
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The PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.
Literature References
PubMed ID Title Journal Year
14749774 The enzymes and control of eukaryotic mRNA turnover

Song, H, Parker, R

Nat Struct Mol Biol 2004
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
10882133 Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro

Fritz, DT, Gao, M, Wilusz, J, Ford, LP

Mol Cell 2000
17052452 Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation

Richter, JD, Kim, JH

Mol Cell 2006
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Wilusz, J, Bergman, N, Wilusz, CJ, Kilpatrick, WJ

Cell Biochem Biophys 2004
9099687 Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease

Körner, CG, Wahle, E

J Biol Chem 1997
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
1355481 Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA

Aström, A, Aström, J, Virtanen, A

J Biol Chem 1992
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
11283721 The cap-to-tail guide to mRNA turnover

Wormington, M, Wilusz, CJ, Peltz, SW

Nat Rev Mol Cell Biol 2001
Catalyst Activity

poly(A)-specific ribonuclease activity of PARN homodimer [cytosol]

Orthologous Events
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