PARN deadenylates mRNA

Stable Identifier
R-HSA-429992
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.

Literature References
PubMed ID Title Journal Year
16141059 From birth to death: the complex lives of eukaryotic mRNAs

Moore, MJ

Science 2005
14749774 The enzymes and control of eukaryotic mRNA turnover

Parker, R, Song, H

Nat Struct Mol Biol 2004
10882133 Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro

Gao, M, Fritz, DT, Ford, LP, Wilusz, J

Mol Cell 2000
17052452 Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation

Kim, JH, Richter, JD

Mol Cell 2006
15475613 Messenger RNA decay in mammalian cells: the exonuclease perspective

Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J

Cell Biochem Biophys 2004
9099687 Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease

Körner, CG, Wahle, E

J Biol Chem 1997
19239894 The many pathways of RNA degradation

Houseley, J, Tollervey, D

Cell 2009
1355481 Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA

Aström, J, Aström, A, Virtanen, A

J Biol Chem 1992
17245413 The highways and byways of mRNA decay

Garneau, NL, Wilusz, J, Wilusz, CJ

Nat Rev Mol Cell Biol 2007
11283721 The cap-to-tail guide to mRNA turnover

Wilusz, CJ, Wormington, M, Peltz, SW

Nat Rev Mol Cell Biol 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
poly(A)-specific ribonuclease activity of PARN homodimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created