Reactome | PARN deadenylates mRNA

PARN deadenylates mRNA

Stable Identifier

R-HSA-429992

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.

Literature References

PubMed ID	Title	Journal	Year
14749774	The enzymes and control of eukaryotic mRNA turnover Parker, R, Song, H	Nat Struct Mol Biol	2004
16141059	From birth to death: the complex lives of eukaryotic mRNAs Moore, MJ	Science	2005
10882133	Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro Gao, M, Fritz, DT, Ford, LP, Wilusz, J	Mol Cell	2000
17052452	Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation Kim, JH, Richter, JD	Mol Cell	2006
15475613	Messenger RNA decay in mammalian cells: the exonuclease perspective Fritz, DT, Bergman, N, Kilpatrick, WJ, Wilusz, CJ, Wilusz, J	Cell Biochem Biophys	2004
9099687	Poly(A) tail shortening by a mammalian poly(A)-specific 3'-exoribonuclease Körner, CG, Wahle, E	J Biol Chem	1997
19239894	The many pathways of RNA degradation Houseley, J, Tollervey, D	Cell	2009
1355481	Properties of a HeLa cell 3' exonuclease specific for degrading poly(A) tails of mammalian mRNA Aström, J, Aström, A, Virtanen, A	J Biol Chem	1992
17245413	The highways and byways of mRNA decay Garneau, NL, Wilusz, J, Wilusz, CJ	Nat Rev Mol Cell Biol	2007
11283721	The cap-to-tail guide to mRNA turnover Wilusz, CJ, Wormington, M, Peltz, SW	Nat Rev Mol Cell Biol	2001