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SMG1 [cytosol]
Stable Identifier
R-HSA-927760
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein kinase SMG1, SMG1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1 [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG1 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG1 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG1 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG1 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96Q15 SMG1
Gene Names
SMG1, ATX, KIAA0421, LIP
Chain
chain:1-3661
Reference Genes
BioGPS Gene:23049 SMG1
COSMIC (genes):SMG1 SMG1
CTD Gene:23049 SMG1
dbSNP Gene:23049 SMG1
ENSEMBL:ENSG00000157106 SMG1
HGNC:30045 SMG1
Monarch:23049 SMG1
NCBI Gene:23049 SMG1
OMIM:607032 SMG1
UCSC:Q96Q15 SMG1
Reference Transcript
RefSeq:NM_015092.4 SMG1
Other Identifiers
11728237_at
11728238_x_at
11745197_s_at
11745978_s_at
11761130_x_at
16824481
16825465
17121456
17121458
17121460
17121462
210057_3p_at
210057_PM_at
210057_at
224842_PM_at
224842_at
23049
231989_PM_s_at
231989_s_at
244766_PM_at
244766_at
32636_f_at
32637_r_at
32638_s_at
3652083
3652084
3652085
3652086
3652602
3652611
3652612
3652613
3652614
3652617
3652618
3652621
3652627
3652629
3652630
3652631
3652636
3652646
3652647
3652649
3652655
3652657
3652660
3652663
3652666
3652668
3652670
3652672
3652676
3652677
3652682
3683048
3683049
3683051
3683052
3683053
3683054
3683055
3683056
3683057
3683058
3683059
3683060
3683062
3683063
3683066
3683068
3683069
3683070
3683071
3683072
3683074
3683075
3683077
3683078
3683079
3683080
3683081
3683082
3683083
3683086
3683087
3683088
3683089
3683090
3683091
3683092
3683094
3683095
3683096
3683097
3683098
3683099
3683100
3683101
3683102
3683103
3683104
3683105
3683106
3683110
3683111
3683112
3683113
3683114
3683115
3683116
3683117
3683118
3683119
3683120
3683121
3683122
3683123
3683125
3683127
3683128
3683129
3683130
3683132
3683134
3683135
3683136
3683137
3683139
3683140
3683141
3683142
3683143
3683145
3683146
3683147
3683148
3683149
3683150
3683151
3683152
3683153
3683154
3683155
3683156
3683157
3683158
3683159
3683160
3683161
3683164
3683165
3683166
3683167
3683168
3683169
3683173
3683174
3683175
3683176
3683177
3683178
3683179
3683180
3683181
3683182
3684199
3684200
3684201
3684202
3684204
3684207
3684208
3684211
3684212
3684213
3684215
3684216
3684218
3684219
3684221
3684223
3684226
3684227
3684228
3684229
3684231
3684232
3684234
3684239
3684242
3684243
3684244
3684247
3684248
3684342
3684343
3684344
3684346
3684347
3684348
3684350
3684351
3684352
3684353
3684354
3684355
3684356
3684357
3684358
3684383
3684397
3684411
3684646
3684648
3684649
3684651
3684659
3684662
3684663
3684664
3684667
3684674
3684690
3686932
3686934
3686936
3686937
3686938
3686939
3686940
3686942
3686943
3686944
3686945
3686947
3686949
3686952
3686954
3686955
3686997
3686999
3687000
3687001
3687002
3687003
3687004
3687021
3687022
3687023
3687025
3687027
3687028
3687032
3687035
3687036
3687038
3687040
3687041
3687042
3687046
3687047
3687048
3687049
3687050
3687060
3687178
3687180
3687181
3687182
3687183
3687185
3687186
3687187
3687188
3687189
3687190
3687192
3687193
3687196
3687197
3687198
3687201
3687204
3687634
3687635
3687637
3687638
3687642
3687643
3687647
3687648
3687649
3687650
3687652
3687654
3687656
3687657
3687658
3687660
3687662
3687667
3687668
3687669
3687670
3687671
3687672
3687673
3687676
3687678
3687679
3687680
3687681
3687682
3687683
3687684
3687687
3687688
3687689
3687692
3696969
3696970
3696973
3696974
3696975
3696976
3696980
3696982
3696984
3696985
3696986
3696987
3696988
3696989
3696990
3696992
3696993
3696994
3696995
3696996
3696998
3696999
3697000
3697002
3697003
44139_at
45955_at
7994006
7999841
8000156
8000167
8000217
8000638
8000651
8000687
8000692
8000823
8000834
8002333
A_24_P161600
A_24_P244952
A_32_P116323
A_32_P142881
A_33_P3394517
GE53173
GE85580
GO:0000184
GO:0003677
GO:0003723
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006281
GO:0006406
GO:0006629
GO:0006913
GO:0006974
GO:0016071
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0032204
GO:0033391
GO:0042162
GO:0043226
GO:0046777
GO:0046854
GO:0046872
GO:0060255
GO:0106310
GO:0140096
HMNXSV003025948
HMNXSV003029278
Hs.28631.0.S1_3p_at
Hs.293645.0.A1_3p_at
ILMN_1652996
ILMN_1710192
ILMN_1801383
PH_hs_0027990
TC16000916.hg
TC16000944.hg
TC16000999.hg
TC16001001.hg
TC16001231.hg
TC16001793.hg
TC16001794.hg
TC16001943.hg
TC16002103.hg
U32581_at
g13654279_3p_s_at
g5542015_3p_x_at
p33785
Participates
as a component of
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
Inferred To
Smg1 [cytosol]
(Mus musculus)
Smg1 [cytosol]
(Rattus norvegicus)
Ghost homologue of SMG1 [cytosol]
(Plasmodium falciparum)
Ghost homologue of SMG1 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of SMG1 [cytosol]
(Schizosaccharomyces pombe)
SMG1 [cytosol]
(Bos taurus)
SMG1 [cytosol]
(Canis familiaris)
SMG1 [cytosol]
(Gallus gallus)
SMG1 [cytosol]
(Sus scrofa)
nonC [cytosol]
(Drosophila melanogaster)
smg-1 [cytosol]
(Caenorhabditis elegans)
smg1 [cytosol]
(Danio rerio)
smg1 [cytosol]
(Dictyostelium discoideum)
smg1 [cytosol]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2201
ENSEMBL
ENSP00000402515
,
ENST00000446231
OpenTargets
ENSG00000157106
HPA
ENSG00000157106-SMG1
ZINC - Substances
SMG1_HUMAN
ZINC target
Q96Q15
PRO
Q96Q15
Pharos - Targets
Q96Q15
GlyGen
Q96Q15
ZINC - Predictions - Purchasable
SMG1_HUMAN
HMDB Protein
HMDBP08855
PDB
7PW8
,
7PW6
,
6L54
,
7PW4
,
7PW7
,
6L53
,
7PW9
,
6Z3R
,
6SYT
,
7PW5
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92900 UPF1
2
p-4S-UPF1 [cytosol]
(R-HSA-927856)
UPF1 [cytosol]
(R-HSA-927734)
0.758
7
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.69
4
UniProt:P21709 EPHA1
2
p-Y599,Y605-EPHA1 [plasma membrane]
(R-HSA-3928336)
EPHA1 [plasma membrane]
(R-HSA-211415)
0.527
2
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.499
2
UniProt:Q92540 SMG7
1
SMG7 [cytosol]
(R-HSA-927838)
0.462
2
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