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PABPN1 [nucleoplasm]
Stable Identifier
R-HSA-72008
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Poly(A)-binding protein II, PAB II
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
NS1 Mediated Effects on Host Pathways (Homo sapiens)
Inhibition of Host mRNA Processing and RNA Silencing (Homo sapiens)
Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)
NS1:PAB II Complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Processing of Capped Intronless Pre-mRNA (Homo sapiens)
Processing of Intronless Pre-mRNAs (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
PABPN1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86U42 PABPN1
Gene Names
PABPN1, PAB2, PABP2
Chain
initiator methionine:1, chain:2-306
Reference Genes
BioGPS Gene:8106 PABPN1
COSMIC (genes):PABPN1 PABPN1
CTD Gene:8106 PABPN1
dbSNP Gene:8106 PABPN1
ENSEMBL:ENSG00000100836.11 PABPN1
HGNC:8565 PABPN1
KEGG Gene (Homo sapiens):8106 PABPN1
Monarch:8106 PABPN1
NCBI Gene:8106 PABPN1
OMIM:602279 PABPN1
UCSC:Q86U42 PABPN1
Reference Transcript
RefSeq:NM_004643.3 PABPN1
Other Identifiers
11718844_s_at
11718845_a_at
11763165_at
201544_3p_x_at
201544_PM_x_at
201544_x_at
201545_PM_s_at
201545_s_at
213046_PM_at
213046_at
3529085
3529088
3529090
3529092
3529094
3529096
3529097
3529098
3529099
3529100
3529101
3529102
3529103
3840483
39050_at
7973384
8106
A_14_P111774
A_23_P128828
GE79123
GO:0000165
GO:0003012
GO:0003676
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006396
GO:0006397
GO:0006913
GO:0006936
GO:0016071
GO:0016607
GO:0016973
GO:0023052
GO:0042405
GO:0043226
GO:0070063
GO:0071222
GO:1904247
GO:1990904
HMNXSV003039577
Hs.117176.0.S1_3p_a_at
Hs.117176.0.S1_3p_x_at
Hs.117176.1.S1_3p_at
ILMN_1759154
PH_hs_0006427
TC14002292.hg
g4758875_3p_a_at
Participates
as an input of
Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
Binding of NS1 to poly(A)-binding protein II (PABII) (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
as a component of
NS1:PAB II Complex [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
as an output of
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
Inferred To
Ghost homologue of PABPN1 [nucleoplasm]
(Canis familiaris)
cpb2 [nucleoplasm]
(Xenopus tropicalis)
pab2 [nucleoplasm]
(Schizosaccharomyces pombe)
zgc:85979 [nucleoplasm]
(Danio rerio)
PABPN1 [nucleoplasm]
(Bos taurus)
PABPN1 [nucleoplasm]
(Gallus gallus)
PABPN1 [nucleoplasm]
(Sus scrofa)
Pabp2 [nucleoplasm]
(Drosophila melanogaster)
Pabpn1 [nucleoplasm]
(Mus musculus)
Pabpn1 [nucleoplasm]
(Rattus norvegicus)
pabp-2 [nucleoplasm]
(Caenorhabditis elegans)
pabpn1 [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_004634.1
OpenTargets
ENSG00000100836
GeneCards
Q86U42
HPA
ENSG00000100836-PABPN1
Ensembl
ENST00000216727
,
ENSG00000100836
,
ENSP00000216727
,
ENST00000397276
,
ENSP00000380446
PRO
Q86U42
Pharos - Targets
Q86U42
Orphanet
16602
PDB
3B4D
,
3B4M
,
3UCG
HMDB Protein
HMDBP08498
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.696
5
UniProt:P67809 YBX1
3
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.558
4
UniProt:Q53F19 NCBP3
0.527
5
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
6
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.499
2
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