Reactome | PABPC1 [cytosol]

PABPC1 [cytosol]

Stable Identifier

R-PFA-156803

Type

Protein [EntityWithAccessionedSequence]

Species

Plasmodium falciparum

Compartment

cytosol

Synonyms

C0H5J5

Locations in the PathwayBrowser

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Metabolism of RNA (Plasmodium falciparum)

- Nonsense-Mediated Decay (NMD) (Plasmodium falciparum)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Plasmodium falciparum)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Plasmodium falciparum)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Plasmodium falciparum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Plasmodium falciparum)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Plasmodium falciparum)
        
        Homologues of PABPC1 [cytosol] (Plasmodium falciparum)
        
        PABPC1 [cytosol] (Plasmodium falciparum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Plasmodium falciparum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Plasmodium falciparum)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Plasmodium falciparum)
        
        Homologues of PABPC1 [cytosol] (Plasmodium falciparum)
        
        PABPC1 [cytosol] (Plasmodium falciparum)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Plasmodium falciparum)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Plasmodium falciparum)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Plasmodium falciparum)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Plasmodium falciparum)
        
        Homologues of PABPC1 [cytosol] (Plasmodium falciparum)
        
        PABPC1 [cytosol] (Plasmodium falciparum)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Plasmodium falciparum)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Plasmodium falciparum)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Plasmodium falciparum)
        
        Homologues of PABPC1 [cytosol] (Plasmodium falciparum)
        
        PABPC1 [cytosol] (Plasmodium falciparum)
- Regulation of mRNA stability by proteins that bind AU-rich elements (Plasmodium falciparum)
  - AUF1 (hnRNP D0) binds and destabilizes mRNA (Plasmodium falciparum)
    - AUF1 (hnRNP D0) is ubiquitinylated (Plasmodium falciparum)
      - AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Plasmodium falciparum)
        
        Homologues of PABPC1 [cytosol] (Plasmodium falciparum)
        
        PABPC1 [cytosol] (Plasmodium falciparum)

Metabolism of proteins (Plasmodium falciparum)

- Translation (Plasmodium falciparum)
  - Eukaryotic Translation Initiation (Plasmodium falciparum)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Plasmodium falciparum)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Plasmodium falciparum)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Plasmodium falciparum)
        
        Homologues of PABPC1 [cytosol] (Plasmodium falciparum)
        
        PABPC1 [cytosol] (Plasmodium falciparum)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Plasmodium falciparum)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Plasmodium falciparum)
        
        Homologues of PABPC1 [cytosol] (Plasmodium falciparum)
        
        PABPC1 [cytosol] (Plasmodium falciparum)

External Reference Information

External Reference

UniProt:C0H5J5

Reference Genes

BioGPS Gene:813867

ENSEMBL:PF3D7_1360900.1

KEGG:pfa:PF3D7_1360900.1

Monarch:813867

NCBI Gene:813867

PlasmoDB:PF3D7_1360900.1

UCSC:C0H5J5

Reference Transcript

RefSeq:XM_024473249.1

Participates

as a member of

Homologues of PABPC1 [cytosol] (Plasmodium falciparum)

Inferred From

PABPC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_024328979.1