Reactome | Dmel\CG4612 [cytosol]

Dmel\CG4612 [cytosol]

Stable Identifier

R-DME-156803-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

PABPC1, Q9W158

Locations in the PathwayBrowser

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Metabolism of RNA (Drosophila melanogaster)

- Deadenylation-dependent mRNA decay (Drosophila melanogaster)
  - Deadenylation of mRNA (Drosophila melanogaster)
    - PAN2-PAN3 complex partially deadenylates mRNA (Drosophila melanogaster)
      - Partially Deadenylated mRNA Complex [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)
      - Translatable mRNA Complex [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)
- Nonsense-Mediated Decay (NMD) (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Drosophila melanogaster)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)
    - SMG6 hydrolyzes mRNA with premature termination codon (Drosophila melanogaster)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        mRNA Complex with a Premature Termination Codon Preceding an Exon Junction [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)
      - mRNA Cleaved by SMG6 [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Drosophila melanogaster)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Drosophila melanogaster)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Drosophila melanogaster)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Drosophila melanogaster)
        
        mRNA Complex with a Premature Termination Codon Not Preceding an Exon Junction [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)
- Regulation of mRNA stability by proteins that bind AU-rich elements (Drosophila melanogaster)
  - AUF1 (hnRNP D0) binds and destabilizes mRNA (Drosophila melanogaster)
    - AUF1 (hnRNP D0) is ubiquitinylated (Drosophila melanogaster)
      - AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] (Drosophila melanogaster)
        
        Homologues of PABPC1 [cytosol] (Drosophila melanogaster)
        
        Dmel\CG4612 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9W158

Gene Names

Dmel\CG4612

Reference Genes

BioGPS Gene:37914 Dmel\CG4612

ENSEMBL:FBgn0035016

FlyBase:FBgn0035016

KEGG:dme:Dmel_CG4612 Dmel\CG4612

Monarch:37914 Dmel\CG4612

NCBI Gene:37914 Dmel\CG4612

UCSC:Q9W158 Dmel\CG4612

Reference Transcript

Other Identifiers

147866_at

1627151_at

37914

GO:0003676

GO:0003723

GO:0003729

GO:0003730

GO:0005634

GO:0005829

GO:0007616

GO:0008143

GO:0008266

GO:0010494

GO:0045727

GO:0050877

GO:1990904

Participates

as a member of

Homologues of PABPC1 [cytosol] (Drosophila melanogaster)

Inferred From

PABPC1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001246493.1, NP_611924.1

FlyBase

FBgn0035016

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