AUF1 binds translation and heat shock proteins

Stable Identifier
R-HSA-450551
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AUF1 binds translation and heat shock proteins
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Tetrameric AUF1 bound to RNA forms a complex with other proteins, including elongation factor eIF4G, polyA-binding protein PABP, Hsp, Hsc70, and Hsp27. AUF1 also directly interacts with polyadenylate.

Literature References
PubMed ID Title Journal Year
16556936 Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay

Schneider, RJ, Bergman, N, Sadri, N, Lu, JY

RNA 2006
10205060 Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

Brewer, G, Schneider, RJ, Laroia, G, Cuesta, R

Science 1999
12819195 Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1

Brewer, G, Wilson, GM, Huynh, Y, Sun, Y, Lu, J, Sutphen, K

J Biol Chem 2003
18573886 Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay

Brewer, G, Sinsimer, KS, Krause, CD, Rivera, YM, Turrin, DK, Scrudato, S, Gupta, S, Wierzbowski, AV, Lu, J, Maher, LR, Knapinska, AM, Pestka, S, De La Cruz, MP, Gratacos, FM

Mol Cell Biol 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
AUF1 binds translation and heat shock proteins (Danio rerio)
Authored
May, B  (2009-12-29)
Reviewed
Wilusz, J  (2010-06-29)
Created
May, B  (2009-12-16)
Cite Us!