AUF1 binds translation and heat shock proteins

Stable Identifier
Homo sapiens
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Tetrameric AUF1 bound to RNA forms a complex with other proteins, including elongation factor eIF4G, polyA-binding protein PABP, Hsp, Hsc70, and Hsp27. AUF1 also directly interacts with polyadenylate.

Literature References
PubMed ID Title Journal Year
16556936 Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay

Schneider, RJ, Bergman, N, Sadri, N, Lu, JY

RNA 2006
10205060 Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

Brewer, G, Schneider, RJ, Laroia, G, Cuesta, R

Science 1999
12819195 Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1

Brewer, G, Wilson, GM, Huynh, Y, Sun, Y, Lu, J, Sutphen, K

J Biol Chem 2003
18573886 Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay

Brewer, G, Sinsimer, KS, Krause, CD, Rivera, YM, Turrin, DK, Scrudato, S, Gupta, S, Wierzbowski, AV, Lu, J, Maher, LR, Knapinska, AM, Pestka, S, De La Cruz, MP, Gratacos, FM

Mol Cell Biol 2008
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