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GSPT1 [cytosol]
Stable Identifier
R-HSA-8865759
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, eRF3a, Eukaryotic peptide chain release factor subunit 3a, ERF3A, G1 to S phase transition protein 1 homolog, ERF3A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP [cytosol] (Homo sapiens)
eRF3:GTP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP [cytosol] (Homo sapiens)
eRF3:GTP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP [cytosol] (Homo sapiens)
eRF3:GTP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer (Homo sapiens)
ETF1 dimer:eRF3:GTP [cytosol] (Homo sapiens)
eRF3:GTP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP [cytosol] (Homo sapiens)
eRF3:GTP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:tRNA Complex [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP [cytosol] (Homo sapiens)
eRF3:GDP [cytosol] (Homo sapiens)
eRF3 [cytosol] (Homo sapiens)
GSPT1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15170 GSPT1
Gene Names
GSPT1, ERF3A
Chain
chain:1-499
Reference Genes
BioGPS Gene:2935 GSPT1
COSMIC (genes):GSPT1 GSPT1
CTD Gene:2935 GSPT1
dbSNP Gene:2935 GSPT1
ENSEMBL:ENSG00000103342 GSPT1
ENSEMBL_homo_sapiens_GENE:ENSG00000103342.13 GSPT1
HGNC:4621 GSPT1
KEGG Gene (Homo sapiens):2935 GSPT1
Monarch:2935 GSPT1
NCBI Gene:2935 GSPT1
OMIM:139259 GSPT1
UCSC:P15170 GSPT1
Reference Transcript
RefSeq:NM_001130006.1 GSPT1
RefSeq:NM_001130007.1 GSPT1
Other Identifiers
11718221_a_at
11718222_s_at
11718223_a_at
11718224_s_at
11742750_a_at
16824004
201912_PM_s_at
201912_s_at
215438_3p_x_at
215438_PM_x_at
215438_x_at
217595_PM_at
217595_at
225276_PM_at
225276_at
234975_PM_at
234975_at
2935
33932_at
3680611
3680612
3680613
3680614
3680615
3680616
3680617
3680618
3680619
3680620
3680621
3680622
3680623
3680625
3680626
3680628
3680630
3680633
3680634
3680636
3680638
3680643
3680645
3680648
3680649
3680660
3680661
3680662
58486_at
64091_at
7999532
80058_at
81055_at
A_23_P206301
A_24_P73669
GE59750
GE789017
GO:0000082
GO:0000166
GO:0000184
GO:0000278
GO:0003723
GO:0003747
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005737
GO:0005829
GO:0005840
GO:0006412
GO:0006415
GO:0006449
GO:0006479
GO:0016071
GO:0016787
GO:0018444
GO:0022626
GO:0036211
GO:0043226
GO:0045182
HMNXSV003018966
Hs.10592.0.A1_3p_at
Hs.237849.0.A1_3p_at
Hs.2707.2.S1_3p_a_at
Hs.2707.2.S1_3p_x_at
Hs.32204.0.A1_3p_at
PH_hs_0000352
PH_hs_0039013
TC16000875.hg
TC16001776.hg
X17644_s_at
g4504166_3p_a_at
Participates
as a member of
eRF3 [cytosol] (Homo sapiens)
Inferred To
eRF3 [cytosol]
(Drosophila melanogaster)
gspt1 [cytosol]
(Danio rerio)
Gspt1 [cytosol]
(Rattus norvegicus)
GSPT1 [cytosol]
(Bos taurus)
GSPT1 [cytosol]
(Canis familiaris)
GSPT1 [cytosol]
(Dictyostelium discoideum)
GSPT1 [cytosol]
(Mus musculus)
GSPT1 [cytosol]
(Plasmodium falciparum)
GSPT1 [cytosol]
(Saccharomyces cerevisiae)
GSPT1 [cytosol]
(Schizosaccharomyces pombe)
GSPT1 [cytosol]
(Sus scrofa)
erfa-3 [cytosol]
(Caenorhabditis elegans)
GSPT2 [cytosol]
(Gallus gallus)
Cross References
RefSeq
NP_001123478.1
,
NP_001123479.1
OpenTargets
ENSG00000103342
GeneCards
P15170
HPA
ENSG00000103342-GSPT1
Ensembl
ENSP00000454351
,
ENST00000563468
,
ENST00000434724
,
ENSP00000398131
,
ENST00000420576
,
ENST00000439887
,
ENSG00000103342
,
ENSP00000408399
,
ENSP00000399539
PRO
P15170
Pharos - Targets
P15170
HMDB Protein
HMDBP08382
PDB
3E1Y
,
4D61
,
3J5Y
,
3KUI
,
6XK9
,
5HXB
,
5LZT
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62495 ETF1
3
Me-Q185-ETF1 [cytosol]
(R-HSA-6800157)
4OHK63-ETF1 [cytosol]
(R-HSA-9629948)
ETF1 [cytosol]
(R-HSA-54433)
0.72
4
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