Reactome | p21 RAS:GDP [plasma membrane]

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p21 RAS:GDP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9632908] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9029158] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS - Homo sapiens [Reaction:R-HSA-5637806] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) - Homo sapiens [Reaction:R-HSA-5637808] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) - Homo sapiens [Reaction:R-HSA-1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) - Homo sapiens [Reaction:R-HSA-1225951] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) - Homo sapiens [Reaction:R-HSA-9672163] SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672170] SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors - Homo sapiens [Reaction:R-HSA-9634418] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 - Homo sapiens [Reaction:R-HSA-9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 - Homo sapiens [Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants - Homo sapiens [Reaction:R-HSA-9665009] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR - Homo sapiens [Reaction:R-HSA-9665707] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR - Homo sapiens [Reaction:R-HSA-9665700] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants - Homo sapiens [Reaction:R-HSA-9703441] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants - Homo sapiens [Reaction:R-HSA-9695853] FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS - Homo sapiens [Reaction:R-HSA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-9026891] NTRK2 activates RAS signaling through SHC1 - Homo sapiens [BlackBoxEvent:R-HSA-9032067] NTRK2 activates RAS signaling through FRS2 - Homo sapiens [BlackBoxEvent:R-HSA-9036970] NTRK3 activates RAS through SHC1 - Homo sapiens [Reaction:R-HSA-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP - Homo sapiens [Reaction:R-HSA-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Homo sapiens [Reaction:R-HSA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Homo sapiens [Reaction:R-HSA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Homo sapiens [Reaction:R-HSA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Homo sapiens [Reaction:R-HSA-9649735] Intrinsic nucleotide exchange on RAS - Homo sapiens [Reaction:R-HSA-1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. - Homo sapiens [Reaction:R-HSA-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Homo sapiens [Reaction:R-HSA-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) - Homo sapiens [Reaction:R-HSA-5686318] GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS - Homo sapiens [Reaction:R-HSA-109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS - Homo sapiens [Reaction:R-HSA-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) - Homo sapiens [Reaction:R-HSA-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-442732] NMDA-activated RASGRF1 activates RAS - Homo sapiens [Reaction:R-HSA-109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS - Homo sapiens [Reaction:R-HSA-5686071] GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS - Homo sapiens [Reaction:R-HSA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Homo sapiens [Reaction:R-HSA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Homo sapiens [Reaction:R-HSA-9670436] p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS - Homo sapiens [Reaction:R-HSA-5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5655241] Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5655277] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [BlackBoxEvent:R-HSA-5621573] CD209 activate GTPase RAS - Homo sapiens [Reaction:R-HSA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Homo sapiens [Reaction:R-HSA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-2424477] SOS mediated nucleotide exchange of RAS (SHC) - Homo sapiens [Reaction:R-HSA-5654647] Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-1433471] Activation of RAS by p-KIT bound SOS1 - Homo sapiens [Reaction:R-HSA-5654600] Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
created	[InstanceEdit:109781] Schmidt, EE, 2004-01-21 04:32:59
dbId	109796
displayName	p21 RAS:GDP [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29420] GDP [cytosol] [DefinedSet:R-HSA-9649715] mature p21 RAS [plasma membrane]
inDisease	false
includedLocation	[Compartment:70101] cytosol
inferredTo	[Complex:R-MMU-109796] p21 RAS:GDP [plasma membrane] - Mus musculus [Complex:R-RNO-109796] p21 RAS:GDP [plasma membrane] - Rattus norvegicus [Complex:R-CFA-109796] p21 RAS:GDP [plasma membrane] - Canis familiaris [Complex:R-BTA-109796] p21 RAS:GDP [plasma membrane] - Bos taurus [Complex:R-SSC-109796] p21 RAS:GDP [plasma membrane] - Sus scrofa [Complex:R-DRE-109796] p21 RAS:GDP [plasma membrane] - Danio rerio [Complex:R-XTR-109796] p21 RAS:GDP [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-109796] p21 RAS:GDP [plasma membrane] - Gallus gallus [Complex:R-DME-109796] p21 RAS:GDP [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-109796] p21 RAS:GDP [plasma membrane] - Caenorhabditis elegans
modified	[InstanceEdit:9658203] Rothfels, Karen, 2019-08-12
name	p21 RAS:GDP
producedByEvent	[Reaction:R-HSA-9649733] mature p21 RAS binds GDP - Homo sapiens [Reaction:R-HSA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Homo sapiens [Reaction:R-HSA-5658231] RAS GAPs stimulate RAS GTPase activity - Homo sapiens [Reaction:R-HSA-8981353] RASA1 stimulates RAS GTPase activity - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-109796

Referrals

(hasComponent)	[Complex:R-HSA-9632908] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane]
(input)	[Reaction:R-HSA-9029158] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS [Reaction:R-HSA-5637806] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) [Reaction:R-HSA-5637808] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) [Reaction:R-HSA-1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) [Reaction:R-HSA-1225951] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) [Reaction:R-HSA-9672163] SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers [Reaction:R-HSA-9672170] SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors [Reaction:R-HSA-9634418] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 [Reaction:R-HSA-9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2 [Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 [Reaction:R-HSA-9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants [Reaction:R-HSA-9665009] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR [Reaction:R-HSA-9665707] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR [Reaction:R-HSA-9665700] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants [Reaction:R-HSA-9703441] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants [Reaction:R-HSA-9695853] FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS [Reaction:R-HSA-9670436] p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS [Reaction:R-HSA-5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-5655241] Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-5655277] Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-HSA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-HSA-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-9026891] NTRK2 activates RAS signaling through SHC1 [BlackBoxEvent:R-HSA-9032067] NTRK2 activates RAS signaling through FRS2 [BlackBoxEvent:R-HSA-9036970] NTRK3 activates RAS through SHC1 [BlackBoxEvent:R-HSA-5621573] CD209 activate GTPase RAS [Reaction:R-HSA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) [Reaction:R-HSA-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP [Reaction:R-HSA-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange [Reaction:R-HSA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 [Reaction:R-HSA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET [Reaction:R-HSA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 [Reaction:R-HSA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET [Reaction:R-HSA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 [Reaction:R-HSA-9649735] Intrinsic nucleotide exchange on RAS [Reaction:R-HSA-1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers. [Reaction:R-HSA-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers [Reaction:R-HSA-1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers [Reaction:R-HSA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) [Reaction:R-HSA-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) [Reaction:R-HSA-5686318] GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS [Reaction:R-HSA-109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS [Reaction:R-HSA-2424477] SOS mediated nucleotide exchange of RAS (SHC) [Reaction:R-HSA-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) [Reaction:R-HSA-5654647] Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-HSA-442732] NMDA-activated RASGRF1 activates RAS [Reaction:R-HSA-1433471] Activation of RAS by p-KIT bound SOS1 [Reaction:R-HSA-109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS [Reaction:R-HSA-5686071] GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS [Reaction:R-HSA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras [Reaction:R-HSA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-HSA-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-5654600] Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-9632906] PRKCZ recruits RAS in response to estrogen stimulation
(output)	[Reaction:R-HSA-9649733] mature p21 RAS binds GDP [Reaction:R-HSA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP [Reaction:R-HSA-5658231] RAS GAPs stimulate RAS GTPase activity [Reaction:R-HSA-8981353] RASA1 stimulates RAS GTPase activity

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