Reactome | p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS

Schema > Reaction > Entries

p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS Show undefined attributes

authored	[InstanceEdit:9681395] Rothfels, Karen, 2020-04-01
catalystActivity	[CatalystActivity:9670404] guanyl-nucleotide exchange factor activity of p-KIT mutants:GRB2:SOS [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643460] Ras guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-KIT complex [plasma membrane] Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9670437] Rothfels, Karen, 2019-12-09
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9670436
disease	[Disease:1500689] cancer
displayName	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS
edited	[InstanceEdit:9686618] Rothfels, Karen, 2020-05-04
entityFunctionalStatus	[EntityFunctionalStatus:9670400] gain_of_function of p-KIT mutants:GRB2:SOS [plasma membrane]
eventOf	[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9670475] Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant [LiteratureReference:9670319] Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients [LiteratureReference:9670502] c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes [LiteratureReference:9670495] Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors [LiteratureReference:9669228] Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells [LiteratureReference:9669245] Stem cell factor receptor/c-Kit: from basic science to clinical implications [LiteratureReference:9679965] ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS
normalReaction	[Reaction:R-HSA-1433471] Activation of RAS by p-KIT bound SOS1
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9670428] KIT mutants bind GRB2-SOS - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9678239] Serrano, C�sar, 2020-03-13 [InstanceEdit:9678232] Garc�a-Valverde, Alfonso, 2020-03-13 [InstanceEdit:9678237] Pilco-Janeta, Daniel, 2020-03-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670436
summation	[Summation:9670519] Activation of the MAP kinase signaling pathway downstream of...

Referrals

(hasEvent)

[Pathway:R-HSA-9670439] Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants