Reactome | SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors

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SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors Show undefined attributes

authored	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
catalystActivity	[CatalystActivity:9672171] guanyl-nucleotide exchange factor activity of p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9672161] Rothfels, Karen, 2019-12-23
dbId	9672170
disease	[Disease:1500689] cancer
displayName	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
edited	[InstanceEdit:9677035] Rothfels, Karen, 2020-02-25
entityFunctionalStatus	[EntityFunctionalStatus:9672146] gain_of_function of p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]
eventOf	[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9671898] PDGFRA activating mutations in gastrointestinal stromal tumors [LiteratureReference:9671911] PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib [LiteratureReference:9673503] Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha [LiteratureReference:9671907] PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations [LiteratureReference:9673518] Gastrointestinal stromal tumours: origin and molecular oncology [LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors
normalReaction	[Reaction:R-HSA-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-186826] GRB2:SOS1 complex binds to the active receptor - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9676030] Ip, Carman K M, 2020-02-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9672170
summation	[Summation:9673733] SOS-mediated exchange of GTP for GDP on RAS is predicted to ...

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(hasEvent)

[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants