Reactome | RAS GAPs stimulate RAS GTPase activity

Schema > Reaction > Entries

RAS GAPs stimulate RAS GTPase activity Show undefined attributes

authored	[InstanceEdit:5656075] Rothfels, Karen, 2014-12-10
catalystActivity	[CatalystActivity:5658230] GTPase activity of p21 RAS:GTP:RAS GAPs [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5658237] Rothfels, Karen, 2014-12-18
dbId	5658231
deleted	[Deleted:9014011] Deletion of instance: 5658218
diseaseReaction	[FailedReaction:R-HSA-6802837] Loss-of-function NF1 variants don't stimulate RAS GTPase activity - Homo sapiens
displayName	RAS GAPs stimulate RAS GTPase activity
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5658442] Regulation of RAS by GAPs - Homo sapiens
input	[Complex:R-HSA-5658227] p21 RAS:GTP:RAS GAPs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5658234] Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	RAS GAPs stimulate RAS GTPase activity
orthologousEvent	[Reaction:R-RNO-5658231] RAS GAPs stimulate RAS GTPase activity - Rattus norvegicus [Reaction:R-DDI-5658231] RAS GAPs stimulate RAS GTPase activity - Dictyostelium discoideum [Reaction:R-DME-5658231] RAS GAPs stimulate RAS GTPase activity - Drosophila melanogaster [Reaction:R-GGA-5658231] RAS GAPs stimulate RAS GTPase activity - Gallus gallus [Reaction:R-DRE-5658231] RAS GAPs stimulate RAS GTPase activity - Danio rerio [Reaction:R-SSC-5658231] RAS GAPs stimulate RAS GTPase activity - Sus scrofa [Reaction:R-CFA-5658231] RAS GAPs stimulate RAS GTPase activity - Canis familiaris [Reaction:R-MMU-5658231] RAS GAPs stimulate RAS GTPase activity - Mus musculus
output	[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane] [DefinedSet:R-HSA-5658216] RAS GAPs [cytosol]
precedingEvent	[Reaction:R-HSA-5658435] RAS GAPs bind RAS:GTP - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28 [InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5658231
summation	[Summation:5658214] The intrinsic GTPase activity of RAS proteins is stimulated ...
updateTrackers	[UpdateTracker:9780882] Update Tracker - [Reaction:5658231] RAS GAPs stimulate RAS GTPase activity - v62:[removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9780882] Update Tracker - [Reaction:5658231] RAS GAPs stimulate RAS GTPase activity - v62:[removeRegulator]
(replacementInstances)	[Deleted:9014011] Deletion of instance: 5658218
(normalReaction)	[FailedReaction:R-HSA-6802837] Loss-of-function NF1 variants don't stimulate RAS GTPase activity
(hasEvent)	[Pathway:R-HSA-5658442] Regulation of RAS by GAPs

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