RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR

authored
catalystActivity
category transition
compartment
created [InstanceEdit:9665710] Orlic-Milacic, Marija, 2019-10-31
dbId 9665707
disease
displayName RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR
edited
entityFunctionalStatus
eventOf
input
isChimeric false
isInDisease true
isInferred false
literatureReference
modified [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
  • RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR
normalReaction [Reaction:R-HSA-1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
output
precedingEvent
releaseDate 2020-03-17
reviewStatus [ReviewStatus:9821382] five stars
reviewed
schemaClass Reaction
species
stId R-HSA-9665707
summation
Cite Us!