Reactome | SOS1-mediated nucleotide exchange of RAS downstream of FLT3

Schema > Reaction > Entries

SOS1-mediated nucleotide exchange of RAS downstream of FLT3 Show undefined attributes

authored	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
catalystActivity	[CatalystActivity:9607298] guanyl-nucleotide exchange factor activity of Active FLT3:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9607299] Varusai, Thawfeek, 2018-05-02
dbId	9607304
displayName	SOS1-mediated nucleotide exchange of RAS downstream of FLT3
edited	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
followingEvent	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens [Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	SOS1-mediated nucleotide exchange of RAS downstream of FLT3
orthologousEvent	[Reaction:R-CEL-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Caenorhabditis elegans [Reaction:R-DME-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Drosophila melanogaster [Reaction:R-GGA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Gallus gallus [Reaction:R-XTR-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Xenopus tropicalis [Reaction:R-SSC-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Sus scrofa [Reaction:R-BTA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Bos taurus [Reaction:R-CFA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Canis familiaris [Reaction:R-RNO-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Rattus norvegicus [Reaction:R-MMU-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9607301] Active FLT3:GRB2 binds SOS1 - Homo sapiens
releaseDate	2019-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9607304
summation	[Summation:188533] Son of sevenless homolog 1 (SOS1) is the guanine nucleotide ...

Referrals

(hasEvent)	[Pathway:R-HSA-9607240] FLT3 Signaling
(normalReaction)	[Reaction:R-HSA-9695853] FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
(precedingEvent)	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade [Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP