Reactome | GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS

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GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS Show undefined attributes

authored	[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
catalystActivity	[CatalystActivity:109816] guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
dbId	109817
displayName	GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-112412] SOS-mediated signalling - Homo sapiens
figure	[Figure:157830] /figures/SOS_ras_IRS.jpg
followingEvent	[Reaction:R-HSA-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 - Homo sapiens
inferredFrom	[Reaction:R-RNO-112377] Grb2:Sos2:p-Y-Irs1 mediated nucleotide exchange of p21 Ras (IRS) - Rattus norvegicus
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109817
summation	[Summation:157817] SOS promotes the formation of GTP-bound RAS, thus activating...
updateTrackers	[UpdateTracker:9784648] Update Tracker - [Reaction:109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS - v53:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784648] Update Tracker - [Reaction:109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS - v53:[modifyText]
(hasEvent)	[Pathway:R-HSA-112412] SOS-mediated signalling
(precedingEvent)	[Reaction:R-HSA-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
(inferredTo)	[Reaction:R-RNO-112377] Grb2:Sos2:p-Y-Irs1 mediated nucleotide exchange of p21 Ras (IRS)

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