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Schema
>
Reaction
>
Entries
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
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authored
[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:8941611] Rothfels, Karen, 2016-10-05
dbId
8941613
displayName
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
edited
[InstanceEdit:8941650] Rothfels, Karen, 2016-10-05
eventOf
[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
[LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
[LiteratureReference:8941730] The role of Shp2 (PTPN11) in cancer
modified
[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange
orthologousEvent
[Reaction:R-DME-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Drosophila melanogaster
[Reaction:R-GGA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Gallus gallus
[Reaction:R-XTR-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Xenopus tropicalis
[Reaction:R-SSC-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Sus scrofa
[Reaction:R-BTA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Bos taurus
[Reaction:R-CFA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Canis familiaris
[Reaction:R-RNO-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Rattus norvegicus
[Reaction:R-MMU-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Mus musculus
output
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent
[Reaction:R-HSA-5654658] Activated FGFR4:p-FRS bind to PPTN11 - Homo sapiens
regulatedBy
[Requirement:R-HSA-8948404] Requirement by 'Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane]'
releaseDate
2011-09-20
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8941613
summation
[Summation:8941612] RAS nucleotide is stimulated downstream of activated FGFR4 i...
Referrals
(hasEvent)
[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling
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