RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2

authored
catalystActivity
category transition
compartment
created [InstanceEdit:9665414] Orlic-Milacic, Marija, 2019-10-30
crossReference
dbId 9665408
disease
displayName RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
edited
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isChimeric false
isInDisease true
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maxDepth 1
modified [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
  • RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
normalReaction [Reaction:R-HSA-1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers
output
precedingEvent
releaseDate 2020-03-17
reviewStatus [ReviewStatus:9821382] five stars
reviewed
schemaClass Reaction
species
stId R-HSA-9665408
summation
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