Reactome | PRKCZ recruits RAS in response to estrogen stimulation

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PRKCZ recruits RAS in response to estrogen stimulation Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9632905] Rothfels, Karen, 2018-12-24
dbId	9632906
displayName	PRKCZ recruits RAS in response to estrogen stimulation
eventOf	[Pathway:R-HSA-9634635] Estrogen-stimulated signaling through PRKCZ - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9632910] ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-9632918] PRKCZ stimulates RAS nucleotide exchange in response to estrogen - Homo sapiens
input	[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane] [Complex:R-HSA-9632853] PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9632798] Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells [LiteratureReference:9632788] Non-transcriptional action of oestradiol and progestin triggers DNA synthesis [LiteratureReference:9632114] PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells [LiteratureReference:9632805] Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells [LiteratureReference:9632817] p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis [LiteratureReference:9632772] Cell proliferation regulated by estradiol receptor: Therapeutic implications [LiteratureReference:9022229] Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PRKCZ recruits RAS in response to estrogen stimulation
orthologousEvent	[Reaction:R-DDI-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Dictyostelium discoideum [Reaction:R-CEL-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Caenorhabditis elegans [Reaction:R-DME-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Drosophila melanogaster [Reaction:R-GGA-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Gallus gallus [Reaction:R-SSC-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Sus scrofa [Reaction:R-BTA-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Bos taurus [Reaction:R-CFA-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Canis familiaris [Reaction:R-RNO-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Rattus norvegicus [Reaction:R-MMU-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Mus musculus
output	[Complex:R-HSA-9632908] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9632906
summation	[Summation:9632938] RAS is recruited to a complex that also contains SRC, PRKCZ ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9632910] ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus [BlackBoxEvent:R-HSA-9632918] PRKCZ stimulates RAS nucleotide exchange in response to estrogen
(hasEvent)	[Pathway:R-HSA-9634635] Estrogen-stimulated signaling through PRKCZ

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