Reactome | FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS

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FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS Show undefined attributes

authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:9695851] guanyl-nucleotide exchange factor activity of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9695854] Rothfels, Karen, 2020-07-15
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9695853
disease	[Disease:1500689] cancer
displayName	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
entityFunctionalStatus	[EntityFunctionalStatus:9698200] gain_of_function of p-6Y FLT3 mutant dimers:GRB2:SOS1 [plasma membrane]
eventOf	[Pathway:R-HSA-9703648] Signaling by FLT3 ITD and TKD mutants - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways [LiteratureReference:9697896] Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS
normalReaction	[Reaction:R-HSA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9695845] FLT3 mutant dimers:GRB2 bind SOS1 - Homo sapiens
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9695853
summation	[Summation:9697922] SOS1-mediated nucleotide exchange on RAS downstream of activ...

Referrals

(hasEvent)

[Pathway:R-HSA-9703648] Signaling by FLT3 ITD and TKD mutants

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