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Reaction
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Entries
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
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authored
[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity
[CatalystActivity:1225931] guanyl-nucleotide exchange factor activity of Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created
[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03
dbId
1225951
disease
[Disease:1500689] cancer
displayName
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
edited
[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07
[InstanceEdit:1972361] Matthews, L, 2011-11-07
[InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus
[EntityFunctionalStatus:5637730] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane]
eventOf
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
[LiteratureReference:1217508] Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
[LiteratureReference:1228027] EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)
normalReaction
[Reaction:R-HSA-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
output
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent
[Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants - Homo sapiens
releaseDate
2011-12-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1990843] Greulich, H, 2011-11-15
[InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1225951
summation
[Summation:1247552] Based on the wild-type EGFR signaling, it is assumed that th...
Referrals
(hasEvent)
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
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