Reactome | SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)

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SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
catalystActivity	[CatalystActivity:180290] guanyl-nucleotide exchange factor activity of EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
dbId	177945
diseaseReaction	[Reaction:R-HSA-5637808] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) - Homo sapiens [Reaction:R-HSA-1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) - Homo sapiens
displayName	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-180336] SHC1 events in EGFR signaling - Homo sapiens
figure	[Figure:179426] /figures/sos_acts_ras.jpg
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
orthologousEvent	[Reaction:R-RNO-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Rattus norvegicus [Reaction:R-CEL-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Caenorhabditis elegans [Reaction:R-DME-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Drosophila melanogaster [Reaction:R-GGA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Gallus gallus [Reaction:R-XTR-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Xenopus tropicalis [Reaction:R-DRE-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Danio rerio [Reaction:R-SSC-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Sus scrofa [Reaction:R-BTA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Bos taurus [Reaction:R-CFA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Canis familiaris [Reaction:R-MMU-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-177945
summation	[Summation:188533] Son of sevenless homolog 1 (SOS1) is the guanine nucleotide ...
updateTrackers	[UpdateTracker:9778566] Update Tracker - [Reaction:177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - v68:[modifyText] [UpdateTracker:9789169] Update Tracker - [Reaction:177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - v38:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9778566] Update Tracker - [Reaction:177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - v68:[modifyText] [UpdateTracker:9789169] Update Tracker - [Reaction:177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - v38:[modifyText]
(normalReaction)	[Reaction:R-HSA-5637808] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) [Reaction:R-HSA-1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
(hasEvent)	[Pathway:R-HSA-180336] SHC1 events in EGFR signaling

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