Reactome | p21 RAS:GDP [plasma membrane]

Schema > Complex > Entries

p21 RAS:GDP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-GGA-9632908] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] - Gallus gallus
consumedByEvent	[Reaction:R-GGA-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) - Gallus gallus [Reaction:R-GGA-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) - Gallus gallus [Reaction:R-GGA-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Gallus gallus [Reaction:R-GGA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Gallus gallus [Reaction:R-GGA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP - Gallus gallus [Reaction:R-GGA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Gallus gallus [Reaction:R-GGA-9649735] Intrinsic nucleotide exchange on RAS - Gallus gallus [Reaction:R-GGA-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) - Gallus gallus [Reaction:R-GGA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Gallus gallus [Reaction:R-GGA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Gallus gallus [Reaction:R-GGA-5672965] RAS GEFs promote RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Gallus gallus [Reaction:R-GGA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Gallus gallus [Reaction:R-GGA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Gallus gallus [Reaction:R-GGA-1433471] Activation of RAS by p-KIT bound SOS1 - Gallus gallus [Reaction:R-GGA-2424477] SOS mediated nucleotide exchange of RAS (SHC) - Gallus gallus [Reaction:R-GGA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Gallus gallus [Reaction:R-GGA-5654600] Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-5654647] Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-GGA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Gallus gallus
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10744470
displayName	p21 RAS:GDP [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29420] GDP [cytosol] [DefinedSet:R-GGA-9649715] mature p21 RAS [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane] - Homo sapiens
maxDepth	3
name	p21 RAS:GDP
producedByEvent	[Reaction:R-GGA-5658231] RAS GAPs stimulate RAS GTPase activity - Gallus gallus [Reaction:R-GGA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Gallus gallus [Reaction:R-GGA-9649733] mature p21 RAS binds GDP - Gallus gallus [Reaction:R-GGA-8981353] RASA1 stimulates RAS GTPase activity - Gallus gallus
schemaClass	Complex
species	[Species:49591] Gallus gallus
stId	R-GGA-109796
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-GGA-1433471] Activation of RAS by p-KIT bound SOS1 [Reaction:R-GGA-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) [Reaction:R-GGA-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) [Reaction:R-GGA-9632906] PRKCZ recruits RAS in response to estrogen stimulation [Reaction:R-GGA-2424477] SOS mediated nucleotide exchange of RAS (SHC) [Reaction:R-GGA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) [Reaction:R-GGA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras [Reaction:R-GGA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-GGA-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-GGA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-GGA-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP [Reaction:R-GGA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-GGA-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-GGA-5654600] Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-GGA-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-GGA-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-GGA-5654647] Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-GGA-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-GGA-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-GGA-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-GGA-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers [Reaction:R-GGA-9649735] Intrinsic nucleotide exchange on RAS [Reaction:R-GGA-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) [Reaction:R-GGA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) [Reaction:R-GGA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 [Reaction:R-GGA-5672965] RAS GEFs promote RAS nucleotide exchange [Reaction:R-GGA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET [Reaction:R-GGA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 [Reaction:R-GGA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET [Reaction:R-GGA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
(hasComponent)	[Complex:R-GGA-9632908] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane]
(output)	[Reaction:R-GGA-5658231] RAS GAPs stimulate RAS GTPase activity [Reaction:R-GGA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP [Reaction:R-GGA-9649733] mature p21 RAS binds GDP [Reaction:R-GGA-8981353] RASA1 stimulates RAS GTPase activity
(inferredTo)	[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]

© 2026 Reactome

Cite Us!