Reactome | SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)

Schema > Reaction > Entries

SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1225930] guanyl-nucleotide exchange factor activity of Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03
dbId	1225957
disease	[Disease:1500689] cancer
displayName	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637720] gain_of_function of Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]
eventOf	[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways [LiteratureReference:1217508] Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins [LiteratureReference:1228027] EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)
normalReaction	[Reaction:R-HSA-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1225957
summation	[Summation:1247603] SOS1 is the guanine nucleotide exchange factor (GEF) for RAS...

Referrals

(hasEvent)

[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Cite Us!