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Schema
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Reaction
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Entries
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
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authored
[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity
[CatalystActivity:5654424] guanyl-nucleotide exchange factor activity of Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5654429] Rothfels, Karen, 2014-12-03
dbId
5654426
displayName
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
eventOf
[Pathway:R-HSA-5654719] SHC-mediated cascade:FGFR4 - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
orthologousEvent
[Reaction:R-CEL-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Caenorhabditis elegans
[Reaction:R-DME-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Drosophila melanogaster
[Reaction:R-GGA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus
[Reaction:R-XTR-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Xenopus tropicalis
[Reaction:R-SSC-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Sus scrofa
[Reaction:R-BTA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Bos taurus
[Reaction:R-CFA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Canis familiaris
[Reaction:R-RNO-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus
[Reaction:R-MMU-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Mus musculus
output
[SimpleEntity:R-ALL-29420] GDP [cytosol]
[Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent
[Reaction:R-HSA-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 - Homo sapiens
releaseDate
2011-09-20
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654426
summation
[Summation:1268274] SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates R...
Referrals
(hasEvent)
[Pathway:R-HSA-5654719] SHC-mediated cascade:FGFR4
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