Reactome | Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

Schema > Reaction > Entries

Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654424] guanyl-nucleotide exchange factor activity of Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654429] Rothfels, Karen, 2014-12-03
dbId	5654426
deleted	[Deleted:5655544] Deletion of instance: 1268277
displayName	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
eventOf	[Pathway:R-HSA-5654719] SHC-mediated cascade:FGFR4 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
orthologousEvent	[Reaction:R-DME-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Drosophila melanogaster [Reaction:R-GGA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-XTR-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Xenopus tropicalis [Reaction:R-DRE-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-SSC-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Sus scrofa [Reaction:R-BTA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Bos taurus [Reaction:R-CFA-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Canis familiaris [Reaction:R-RNO-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-MMU-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654426
summation	[Summation:1268274] SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates R...
updateTrackers	[UpdateTracker:9782516] Update Tracker - [Reaction:5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - v59:[removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9782516] Update Tracker - [Reaction:5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - v59:[removeRegulator]
(replacementInstances)	[Deleted:5655544] Deletion of instance: 1268277
(hasEvent)	[Pathway:R-HSA-5654719] SHC-mediated cascade:FGFR4