Reactome | p21 RAS:GDP [plasma membrane]

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p21 RAS:GDP [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-DRE-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) - Danio rerio [Reaction:R-DRE-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) - Danio rerio [Reaction:R-DRE-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Danio rerio [Reaction:R-DRE-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP - Danio rerio [Reaction:R-DRE-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Danio rerio [Reaction:R-DRE-9649735] Intrinsic nucleotide exchange on RAS - Danio rerio [Reaction:R-DRE-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) - Danio rerio [Reaction:R-DRE-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Danio rerio [Reaction:R-DRE-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Danio rerio [Reaction:R-DRE-5672965] RAS GEFs promote RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Danio rerio [Reaction:R-DRE-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Danio rerio [Reaction:R-DRE-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Danio rerio [Reaction:R-DRE-1433471] Activation of RAS by p-KIT bound SOS1 - Danio rerio [Reaction:R-DRE-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Danio rerio [Reaction:R-DRE-5654600] Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-5654647] Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-DRE-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Danio rerio
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10572353
displayName	p21 RAS:GDP [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29420] GDP [cytosol] [DefinedSet:R-DRE-9649715] mature p21 RAS [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane] - Homo sapiens
maxDepth	3
name	p21 RAS:GDP
producedByEvent	[Reaction:R-DRE-5658231] RAS GAPs stimulate RAS GTPase activity - Danio rerio [Reaction:R-DRE-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Danio rerio [Reaction:R-DRE-9649733] mature p21 RAS binds GDP - Danio rerio [Reaction:R-DRE-8981353] RASA1 stimulates RAS GTPase activity - Danio rerio
schemaClass	Complex
species	[Species:68323] Danio rerio
stId	R-DRE-109796
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-DRE-1433471] Activation of RAS by p-KIT bound SOS1 [Reaction:R-DRE-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) [Reaction:R-DRE-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) [Reaction:R-DRE-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) [Reaction:R-DRE-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras [Reaction:R-DRE-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DRE-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-DRE-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DRE-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP [Reaction:R-DRE-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-DRE-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DRE-5654600] Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DRE-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-DRE-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DRE-5654647] Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DRE-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DRE-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-DRE-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-DRE-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers [Reaction:R-DRE-9649735] Intrinsic nucleotide exchange on RAS [Reaction:R-DRE-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) [Reaction:R-DRE-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) [Reaction:R-DRE-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 [Reaction:R-DRE-5672965] RAS GEFs promote RAS nucleotide exchange [Reaction:R-DRE-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET [Reaction:R-DRE-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 [Reaction:R-DRE-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET [Reaction:R-DRE-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
(output)	[Reaction:R-DRE-5658231] RAS GAPs stimulate RAS GTPase activity [Reaction:R-DRE-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP [Reaction:R-DRE-9649733] mature p21 RAS binds GDP [Reaction:R-DRE-8981353] RASA1 stimulates RAS GTPase activity
(inferredTo)	[Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]

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