Reactome | NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras

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NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras Show undefined attributes

authored	[InstanceEdit:391809] Garapati, P V, 2009-02-24 10:31:15
catalystActivity	[CatalystActivity:392052] guanyl-nucleotide exchange factor activity of Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:392050] Garapati, P V, 2009-02-26 17:43:29
dbId	392054
displayName	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
edited	[InstanceEdit:391881] Garapati, P V, 2009-02-24 10:58:20
eventOf	[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
orthologousEvent	[Reaction:R-XTR-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Xenopus tropicalis [Reaction:R-CEL-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Caenorhabditis elegans [Reaction:R-DME-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Drosophila melanogaster [Reaction:R-GGA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Gallus gallus [Reaction:R-SSC-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Sus scrofa [Reaction:R-BTA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Bos taurus [Reaction:R-CFA-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Canis familiaris [Reaction:R-RNO-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Rattus norvegicus [Reaction:R-MMU-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-392053] SOS binds Grb2 bound to pFAK:NCAM1 - Homo sapiens
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422107] Maness, PF, Walmod, PS, 2009-05-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392054
summation	[Summation:392034] The guanine nucleotide exchange factor SOS interacts with GR...

Referrals

(hasEvent)

[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth