Reactome | Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange

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Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654401] guanyl-nucleotide exchange factor activity of Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654400] Rothfels, Karen, 2014-12-03
dbId	5654402
displayName	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
eventOf	[Pathway:R-HSA-5654699] SHC-mediated cascade:FGFR2 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
orthologousEvent	[Reaction:R-CEL-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Caenorhabditis elegans [Reaction:R-DME-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Drosophila melanogaster [Reaction:R-GGA-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-XTR-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Xenopus tropicalis [Reaction:R-DRE-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio [Reaction:R-SSC-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Sus scrofa [Reaction:R-BTA-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Bos taurus [Reaction:R-CFA-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Canis familiaris [Reaction:R-RNO-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-MMU-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654406] Activated FGFR2:p-SHC1 binds GRB2:SOS1 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654402
summation	[Summation:1268274] SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates R...

Referrals

(hasEvent)

[Pathway:R-HSA-5654699] SHC-mediated cascade:FGFR2