Reactome | GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:5686319] guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-3Y-SHC1 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5686317] Jupe, Steve, 2015-04-01
dbId	5686318
displayName	GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
edited	[InstanceEdit:5687546] Jupe, Steve, 2015-04-08
eventOf	[Pathway:R-HSA-2428933] SHC-related events triggered by IGF1R - Homo sapiens
inferredFrom	[Reaction:R-RNO-112378] SOS mediated nucleotide exchange of RAS (SHC) - Rattus norvegicus
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:187761] The structural basis of the activation of Ras by Sos
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-5686073] GRB2-1:SOS1 binds p-3Y-SHC1 - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5686318
summation	[Summation:5686320] SOS promotes the formation of GTP-bound RAS, thus activating...

(hasEvent)	[Pathway:R-HSA-2428933] SHC-related events triggered by IGF1R
(inferredTo)	[Reaction:R-RNO-112378] SOS mediated nucleotide exchange of RAS (SHC)

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