Reactome | Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

Schema > Reaction > Entries

Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:5655287] guanyl-nucleotide exchange factor activity of FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	5655347
deleted	[Deleted:5655673] Deletion of instance: 1982085
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655317] gain_of_function of FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
eventOf	[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:2011995] FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer [LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:2011956] The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells [LiteratureReference:1637849] Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma [LiteratureReference:2032925] Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations [LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation [LiteratureReference:2023814] Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
normalReaction	[Reaction:R-HSA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655347
summation	[Summation:1982087] Activation of Erk1/2 downstream of FGFR mutants suggests tha...
updateTrackers	[UpdateTracker:9775325] Update Tracker - [Reaction:5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - v79:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775325] Update Tracker - [Reaction:5655347] Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - v79:[modifyText]
(replacementInstances)	[Deleted:5655673] Deletion of instance: 1982085
(hasEvent)	[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease