Reactome | Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange

Schema > Reaction > Entries

Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:8941622] Rothfels, Karen, 2016-10-05
dbId	8941623
displayName	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
edited	[InstanceEdit:8941658] Rothfels, Karen, 2016-10-05
eventOf	[Pathway:R-HSA-5654693] FRS-mediated FGFR1 signaling - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:443100] Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation [LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins [LiteratureReference:8941730] The role of Shp2 (PTPN11) in cancer
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange
orthologousEvent	[Reaction:R-SSC-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Sus scrofa [Reaction:R-DME-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Drosophila melanogaster [Reaction:R-GGA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Gallus gallus [Reaction:R-XTR-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Xenopus tropicalis [Reaction:R-DRE-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Danio rerio [Reaction:R-BTA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Bos taurus [Reaction:R-CFA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Canis familiaris [Reaction:R-RNO-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-MMU-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654587] Activated FGFR1:p-FRS phosphorylates PPTN11 - Homo sapiens
regulatedBy	[Requirement:R-HSA-8948406] Requirement by 'Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane]'
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8941623
summation	[Summation:8941624] RAS nucleotide is stimulated downstream of activated FGFR1 i...

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(hasEvent)

[Pathway:R-HSA-5654693] FRS-mediated FGFR1 signaling