Reactome | RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants

Schema > Reaction > Entries

RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants Show undefined attributes

authored	[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019-10-31
catalystActivity	[CatalystActivity:9665880] guanyl-nucleotide exchange factor activity of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9665710] Orlic-Milacic, Marija, 2019-10-31
dbId	9665700
disease	[Disease:1500689] cancer
displayName	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665868] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]
eventOf	[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9665999] Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
normalReaction	[Reaction:R-HSA-1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9666036] Bose, Ron, 2019-10-25 [InstanceEdit:9666034] Krishna, Anagha, 2019-10-25 [InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9665700
summation	[Summation:9665735] Activation of downstream RAS signaling was shown for ERBB2 S...

Referrals

(hasEvent)

[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants

Cite Us!