Reactome | GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS

Schema > Reaction > Entries

GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS Show undefined attributes

authored	[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
catalystActivity	[CatalystActivity:109806] guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-Y427-SHC1 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
dbId	109807
displayName	GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-74751] Insulin receptor signalling cascade - Homo sapiens
figure	[Figure:157816] /figures/SOS_ras_SHC.jpg
followingEvent	[Reaction:R-HSA-170986] Ral-GDS binds to Ras-GTP - Homo sapiens
inferredFrom	[Reaction:R-RNO-112378] SOS mediated nucleotide exchange of RAS (SHC) - Rattus norvegicus
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:187761] The structural basis of the activation of Ras by Sos
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-74746] GRB2-1:SOS1 binds p-Y427-SHC1 - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109807
summation	[Summation:157817] SOS promotes the formation of GTP-bound RAS, thus activating...

Referrals

(hasEvent)	[Pathway:R-HSA-74751] Insulin receptor signalling cascade
(precedingEvent)	[Reaction:R-HSA-170986] Ral-GDS binds to Ras-GTP
(inferredTo)	[Reaction:R-RNO-112378] SOS mediated nucleotide exchange of RAS (SHC)

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