Reactome | RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers

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RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1250510] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
dbId	1250463
diseaseReaction	[Reaction:R-HSA-9634418] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 - Homo sapiens [Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants - Homo sapiens [Reaction:R-HSA-9665700] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants - Homo sapiens
displayName	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
eventOf	[Pathway:R-HSA-1250196] SHC1 events in ERBB2 signaling - Homo sapiens
inferredFrom	[Reaction:R-NUL-1250472] Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1250467] Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1250463
summation	[Summation:1250502] SOS1, bound to GRB2 in complex with phosphorylated SHC1 and ...
updateTrackers	[UpdateTracker:9777583] Update Tracker - [Reaction:1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers - v70:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777583] Update Tracker - [Reaction:1250463] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers - v70:[modifyText]
(normalReaction)	[Reaction:R-HSA-9634418] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 [Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1 [Reaction:R-HSA-9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants [Reaction:R-HSA-9665700] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
(hasEvent)	[Pathway:R-HSA-1250196] SHC1 events in ERBB2 signaling
(inferredTo)	[Reaction:R-NUL-1250472] Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut

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