Reactome | SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)

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SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) Show undefined attributes

authored	[InstanceEdit:2186599] Jassal, Bijay, Tripathi, S, 2012-04-04
catalystActivity	[CatalystActivity:2179400] guanyl-nucleotide exchange factor activity of GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2179414] Jassal, B, 2012-04-04
dbId	2179407
displayName	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
edited	[InstanceEdit:2186599] Jassal, Bijay, Tripathi, S, 2012-04-04
eventOf	[Pathway:R-HSA-2179392] EGFR Transactivation by Gastrin - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)
orthologousEvent	[Reaction:R-CEL-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Caenorhabditis elegans [Reaction:R-DME-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Drosophila melanogaster [Reaction:R-GGA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Gallus gallus [Reaction:R-XTR-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Xenopus tropicalis [Reaction:R-DRE-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Danio rerio [Reaction:R-SSC-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Sus scrofa [Reaction:R-BTA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Bos taurus [Reaction:R-CFA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Canis familiaris [Reaction:R-RNO-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Rattus norvegicus [Reaction:R-MMU-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2206192] D'Eustachio, P, 2012-04-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2179407
summation	[Summation:2179393] SOS1 is the guanine nucleotide exchange factor (GEF) for RAS...

Referrals

(hasEvent)

[Pathway:R-HSA-2179392] EGFR Transactivation by Gastrin