Reactome | NTRK3 activates RAS through SHC1

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9036969] Orlic-Milacic, Marija, 2018-02-14
dbId	9036970
displayName	NTRK3 activates RAS through SHC1
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9034864] Activated NTRK3 signals through RAS - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-9616949] Ntrk3 activates Ras - Rattus norvegicus
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTRK3 activates RAS through SHC1
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9036949] NTRK3 binds GRB2:SOS1 through SHC1 - Homo sapiens
regulatedBy	[PositiveRegulation:9036972] Positive regulation by 'NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1:GRB2:SOS1 [plasma membrane]'
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9036970
summation	[Summation:9036971] Stimulation of NTRK3 (TRKC) by recombinant human NTF3 (NT-3)...

(hasEvent)	[Pathway:R-HSA-9034864] Activated NTRK3 signals through RAS
(inferredTo)	[BlackBoxEvent:R-NUL-9616949] Ntrk3 activates Ras

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