Reactome | RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4

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RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
catalystActivity	[CatalystActivity:1250381] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1250386] Orlic-Milacic, Marija, 2011-04-18
dbId	1250383
displayName	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
eventOf	[Pathway:R-HSA-1250347] SHC1 events in ERBB4 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1250369] A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
orthologousEvent	[Reaction:R-DME-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Drosophila melanogaster [Reaction:R-GGA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Gallus gallus [Reaction:R-XTR-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Xenopus tropicalis [Reaction:R-DRE-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Danio rerio [Reaction:R-SSC-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Sus scrofa [Reaction:R-BTA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Bos taurus [Reaction:R-CFA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Canis familiaris [Reaction:R-RNO-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Rattus norvegicus [Reaction:R-MMU-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11 [InstanceEdit:2104982] Earp HS, 3rd, 2012-02-20 [InstanceEdit:2104979] Misior, AM, 2012-02-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1250383
summation	[Summation:1250384] SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 activa...

Referrals

(hasEvent)	[Pathway:R-HSA-1250347] SHC1 events in ERBB4 signaling
(precedingEvent)	[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange