Reactome | RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers

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RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:1306968] guanyl-nucleotide exchange factor activity of NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1306970] Orlic-Milacic, Marija, 2011-05-27
dbId	1306972
displayName	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
eventOf	[Pathway:R-HSA-1963640] GRB2 events in ERBB2 signaling - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1358721] Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
orthologousEvent	[Reaction:R-CEL-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Caenorhabditis elegans [Reaction:R-DME-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Drosophila melanogaster [Reaction:R-GGA-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Gallus gallus [Reaction:R-XTR-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Xenopus tropicalis [Reaction:R-DRE-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Danio rerio [Reaction:R-SSC-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Sus scrofa [Reaction:R-BTA-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Bos taurus [Reaction:R-CFA-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Canis familiaris [Reaction:R-RNO-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Rattus norvegicus [Reaction:R-MMU-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1306972
summation	[Summation:1358761] SOS1 bound to GRB2 in complex with any of the phosphorylate...

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(hasEvent)

[Pathway:R-HSA-1963640] GRB2 events in ERBB2 signaling