Reactome | SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)

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SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) Show undefined attributes

authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
catalystActivity	[CatalystActivity:5637803] guanyl-nucleotide exchange factor activity of p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5637807] Orlic-Milacic, Marija, 2014-11-12
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	5637806
disease	[Disease:1500689] cancer
displayName	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:9630165] gain_of_function of p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane]
eventOf	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5637789] Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)
normalReaction	[Reaction:R-HSA-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5637806
summation	[Summation:5637744] Based on the wild-type EGFR signaling, it is assumed that th...
updateTrackers	[UpdateTracker:9785526] Update Tracker - [Reaction:5637806] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) - v52:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9785526] Update Tracker - [Reaction:5637806] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) - v52:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII

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