Reactome | RAS GEFs promote RAS nucleotide exchange

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RAS GEFs promote RAS nucleotide exchange Show undefined attributes

authored	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
catalystActivity	[CatalystActivity:5672963] guanyl-nucleotide exchange factor activity of RAS GEFs [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5672964] Rothfels, Karen, 2015-02-06
dbId	5672965
displayName	RAS GEFs promote RAS nucleotide exchange
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-9660557] RAS:GTP binds RAL GDS proteins - Homo sapiens [Reaction:R-HSA-9658253] RAS:GTP binds PI3K - Homo sapiens [Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5672281] Regulation of small GTPases by GEFs, GAPs, and GDIs [LiteratureReference:5672150] Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases [LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway [LiteratureReference:5672270] Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	RAS GEFs promote RAS nucleotide exchange
orthologousEvent	[Reaction:R-DDI-5672965] RAS GEFs promote RAS nucleotide exchange - Dictyostelium discoideum [Reaction:R-CEL-5672965] RAS GEFs promote RAS nucleotide exchange - Caenorhabditis elegans [Reaction:R-DME-5672965] RAS GEFs promote RAS nucleotide exchange - Drosophila melanogaster [Reaction:R-MMU-5672965] RAS GEFs promote RAS nucleotide exchange - Mus musculus [Reaction:R-RNO-5672965] RAS GEFs promote RAS nucleotide exchange - Rattus norvegicus [Reaction:R-CFA-5672965] RAS GEFs promote RAS nucleotide exchange - Canis familiaris [Reaction:R-BTA-5672965] RAS GEFs promote RAS nucleotide exchange - Bos taurus [Reaction:R-SSC-5672965] RAS GEFs promote RAS nucleotide exchange - Sus scrofa [Reaction:R-DRE-5672965] RAS GEFs promote RAS nucleotide exchange - Danio rerio [Reaction:R-XTR-5672965] RAS GEFs promote RAS nucleotide exchange - Xenopus tropicalis [Reaction:R-GGA-5672965] RAS GEFs promote RAS nucleotide exchange - Gallus gallus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654597] Activated FGFR1:p-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654615] Activated FGFR2:pFRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654406] Activated FGFR2:p-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654646] Activated FGFR3:p-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-392053] SOS binds Grb2 bound to pFAK:NCAM1 - Homo sapiens [Reaction:R-HSA-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Homo sapiens [Reaction:R-HSA-1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - Homo sapiens [Reaction:R-HSA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Homo sapiens [Reaction:R-HSA-74746] GRB2-1:SOS1 binds p-Y427-SHC1 - Homo sapiens [Reaction:R-HSA-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Homo sapiens [Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Homo sapiens [Reaction:R-HSA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Homo sapiens [Reaction:R-HSA-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Homo sapiens [Reaction:R-HSA-186826] GRB2:SOS1 complex binds to the active receptor - Homo sapiens [Reaction:R-HSA-210974] Interaction of SOS-1 to Tie2 bound Grb2 - Homo sapiens [BlackBoxEvent:R-HSA-1168374] RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated - Homo sapiens [Reaction:R-HSA-205286] GRB2:SOS interacts with p-KIT - Homo sapiens [Reaction:R-HSA-442760] Activation of RasGRF - Homo sapiens [Reaction:R-HSA-453111] Phosphorylated SHC recruits GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Homo sapiens [Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Homo sapiens [Reaction:R-HSA-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Homo sapiens [Reaction:R-HSA-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5672965
summation	[Summation:5672624] The human genome is predicted to encode 27 RAS guanine nucle...

Referrals

(precedingEvent)	[Reaction:R-HSA-9660557] RAS:GTP binds RAL GDS proteins [Reaction:R-HSA-9658253] RAS:GTP binds PI3K [Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP
(hasEvent)	[Pathway:R-HSA-5673001] RAF/MAP kinase cascade

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