Reactome | Activation of RAS by p-KIT bound SOS1

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Activation of RAS by p-KIT bound SOS1 Show undefined attributes

authored	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
catalystActivity	[CatalystActivity:1433439] guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-KIT complex [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643460] Ras guanyl-nucleotide exchange factor activity of GRB2:SOS1:p-KIT complex [plasma membrane] Stem cell factor and its receptor c-Kit as targets for inflammatory diseases
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1433498] Garapati, P V, 2011-07-11
dbId	1433471
displayName	Activation of RAS by p-KIT bound SOS1
edited	[InstanceEdit:1433337] Garapati, P V, 2011-07-11
eventOf	[Pathway:R-HSA-1433557] Signaling by SCF-KIT - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-109796] p21 RAS:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1433412] p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein [LiteratureReference:205186] Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor [LiteratureReference:1433408] Stem cell factor and its receptor c-Kit as targets for inflammatory diseases [LiteratureReference:1433535] Comparative analysis of signaling pathways between mast cell growth factor (c-kit ligand) and granulocyte-macrophage colony-stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-1, GTPase-activating protein and mitogen-activated protein kinase
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	Activation of RAS by p-KIT bound SOS1
orthologousEvent	[Reaction:R-DRE-1433471] Activation of RAS by p-KIT bound SOS1 - Danio rerio [Reaction:R-CEL-1433471] Activation of RAS by p-KIT bound SOS1 - Caenorhabditis elegans [Reaction:R-DME-1433471] Activation of RAS by p-KIT bound SOS1 - Drosophila melanogaster [Reaction:R-GGA-1433471] Activation of RAS by p-KIT bound SOS1 - Gallus gallus [Reaction:R-XTR-1433471] Activation of RAS by p-KIT bound SOS1 - Xenopus tropicalis [Reaction:R-SSC-1433471] Activation of RAS by p-KIT bound SOS1 - Sus scrofa [Reaction:R-BTA-1433471] Activation of RAS by p-KIT bound SOS1 - Bos taurus [Reaction:R-CFA-1433471] Activation of RAS by p-KIT bound SOS1 - Canis familiaris [Reaction:R-RNO-1433471] Activation of RAS by p-KIT bound SOS1 - Rattus norvegicus [Reaction:R-MMU-1433471] Activation of RAS by p-KIT bound SOS1 - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
precedingEvent	[Reaction:R-HSA-205286] GRB2:SOS interacts with p-KIT - Homo sapiens [Reaction:R-HSA-1433428] GRB2 is indirectly recruited to p-KIT through SHP2 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1500883] R�nnstrand, Lars, 2011-08-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1433471
summation	[Summation:1433470] Once recruited to the membrane in response to c-Kit stimulat...

Referrals

(normalReaction)	[Reaction:R-HSA-9670436] p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS
(hasEvent)	[Pathway:R-HSA-1433557] Signaling by SCF-KIT

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