Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
FCHO2 [cytosol]
Stable Identifier
R-HSA-8862260
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
F-BAR domain only protein 2, FCHO2_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
AAK1 phosphorylates AP-2 mu subunit at T156 (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
Recruitment of AP-2 complex and clathrin (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Homo sapiens)
FCHO1,2 dimer [cytosol] (Homo sapiens)
FCHO2 dimer [cytosol] (Homo sapiens)
FCHO2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q0JRZ9 FCHO2
Gene Names
FCHO2
Chain
chain:1-810
Reference Genes
BioGPS Gene:115548 FCHO2
COSMIC (genes):FCHO2 FCHO2
CTD Gene:115548 FCHO2
dbSNP Gene:115548 FCHO2
ENSEMBL:ENSG00000157107 FCHO2
HGNC:25180 FCHO2
Monarch:115548 FCHO2
NCBI Gene:115548 FCHO2
OMIM:613438 FCHO2
UCSC:Q0JRZ9 FCHO2
Reference Transcript
RefSeq:NM_138782.2 FCHO2
RefSeq:NM_001146032.1 FCHO2
Other Identifiers
115548
11724170_a_at
11724171_a_at
11724172_s_at
11749308_x_at
11749457_a_at
1555153_3p_s_at
1555153_PM_s_at
1555153_s_at
16986033
228220_PM_at
228220_at
2815140
2815141
2815142
2815145
2815146
2815148
2815150
2815167
2815169
2815170
2815176
2815177
2815178
2815179
2815180
2815182
2815186
2815187
2815189
2815190
2815191
2815192
2815194
2815197
2815198
2815199
2815201
2815202
2815203
2815204
2815205
2815206
2815207
2815208
2815209
2815210
2815211
56662_at
8106141
85764_at
A_23_P349083
A_23_P420610
GO:0001786
GO:0005515
GO:0005546
GO:0005737
GO:0005829
GO:0005886
GO:0005905
GO:0006897
GO:0008289
GO:0010324
GO:0016020
GO:0016192
GO:0030136
GO:0031410
GO:0035091
GO:0042802
GO:0043226
GO:0045202
GO:0048268
GO:0048488
GO:0061024
GO:0065003
GO:0072583
GO:0072659
HMNXSV003050552
Hs.24230.0.A1_3p_at
Hs2.356358.1.A1_3p_at
Hs2.356358.1.A1_3p_s_at
ILMN_1670322
PH_hs_0017277
TC05000343.hg
Participates
as a component of
FCHO2 dimer [cytosol] (Homo sapiens)
Inferred To
mgp1 [cytosol]
(Dictyostelium discoideum)
rga9 [cytosol]
(Schizosaccharomyces pombe)
FCHO2 [cytosol]
(Bos taurus)
FCHO2 [cytosol]
(Canis familiaris)
FCHO2 [cytosol]
(Dictyostelium discoideum)
FCHO2 [cytosol]
(Gallus gallus)
FCHO2 [cytosol]
(Sus scrofa)
SYP1 [cytosol]
(Saccharomyces cerevisiae)
Dmel\CG8176 [cytosol]
(Drosophila melanogaster)
fcho-1 [cytosol]
(Caenorhabditis elegans)
imp2 [cytosol]
(Schizosaccharomyces pombe)
cdc15 [cytosol]
(Schizosaccharomyces pombe)
RGD2 [cytosol]
(Saccharomyces cerevisiae)
syp1 [cytosol]
(Schizosaccharomyces pombe)
Fcho2 [cytosol]
(Mus musculus)
Fcho2 [cytosol]
(Rattus norvegicus)
rga8 [cytosol]
(Schizosaccharomyces pombe)
Homologues of FCHO2 [cytosol]
(Dictyostelium discoideum)
Homologues of FCHO2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of FCHO2 [cytosol]
(Schizosaccharomyces pombe)
HOF1 [cytosol]
(Saccharomyces cerevisiae)
Cross References
ENSEMBL
ENST00000512348
,
ENSP00000427296
,
ENST00000430046
,
ENSP00000393776
OpenTargets
ENSG00000157107
HPA
ENSG00000157107-FCHO2
PRO
Q0JRZ9
Pharos - Targets
Q0JRZ9
GlyGen
Q0JRZ9
PDB
2V0O
,
7OI5
,
7OHZ
,
7OG1
,
7OIQ
,
7OIT
,
7OHO
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.695
4
UniProt:P98078
3
Dab2 [cytosol]
(R-MMU-8862456)
Dab2 [lysosomal membrane]
(R-MMU-2980807)
Dab2 [plasma membrane]
(R-MMU-2980808)
0.623
4
UniProt:P98082 DAB2
3
DAB2 [cytosol]
(R-HSA-8862456)
DAB2 [lysosomal membrane]
(R-HSA-2980807)
DAB2 [plasma membrane]
(R-HSA-2980808)
0.527
3
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.527
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text