Reactome | EPS15L1 [plasma membrane]

EPS15L1 [plasma membrane]

Stable Identifier

R-HSA-182937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Eps15R

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        EPS15L1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UBC2 EPS15L1

Gene Names

EPS15L1, EPS15R

Chain

initiator methionine:1, chain:2-864

Reference Genes

BioGPS Gene:58513 EPS15L1

COSMIC (genes):EPS15L1 EPS15L1

CTD Gene:58513 EPS15L1

dbSNP Gene:58513 EPS15L1

ENSEMBL:ENSG00000127527.14 EPS15L1

HGNC:24634 EPS15L1

KEGG Gene (Homo sapiens):58513 EPS15L1

Monarch:58513 EPS15L1

NCBI Gene:58513 EPS15L1

UCSC:Q9UBC2 EPS15L1

Reference Transcript

Other Identifiers

11729752_a_at

11746465_a_at

11759882_a_at

11760280_a_at

11760426_a_at

16869984

221056_PM_x_at

221056_x_at

222112_PM_at

222112_at

222113_PM_s_at

222113_s_at

231926_PM_at

231926_at

232438_PM_at

232438_at

239497_PM_at

239497_at

3853815

3853816

3853825

3853826

3853827

3853832

3853837

3853838

3853841

3853842

3853843

3853846

3853847

3853848

3853849

3853850

3853851

3853852

3853853

3853863

3853866

3853868

3853870

3853871

3853877

3853878

3853879

3853881

3853884

3853888

3853893

3853895

3853896

3853905

3853906

3853907

3853908

53351_at

58513

62047_at

79358_at

8035120

85923_at

A_23_P38941

A_33_P3350828

GE53412

GO:0005509

GO:0005515

GO:0005634

GO:0005829

GO:0005886

GO:0005905

GO:0006897

GO:0016020

GO:0016192

GO:0016197

GO:0030132

GO:0043226

GO:0045296

GO:0046872

HMNXSV003001360

HMNXSV003019275

HMNXSV003026878

HMNXSV003043582

Hs.147176.1.S1_3p_at

Hs.147176.2.S1_3p_at

Hs.192142.0.A1_3p_at

Hs.318510.0.S1_3p_at

ILMN_1708369

PH_hs_0008803

PH_hs_0038197

TC19001265.hg

g10864046_3p_a_at

Participates

as a component of

as an input of

Other forms of this molecule

EPS15L1 [cytosol]

Inferred To

ehs-1 [plasma membrane] (Caenorhabditis elegans)

eps15l1 [plasma membrane] (Xenopus tropicalis)

Eps-15 [plasma membrane] (Drosophila melanogaster)

Eps15l1 [plasma membrane] (Rattus norvegicus)

EPS15L1 [plasma membrane] (Bos taurus)

EPS15L1 [plasma membrane] (Canis familiaris)

EPS15L1 [plasma membrane] (Danio rerio)

EPS15L1 [plasma membrane] (Gallus gallus)

EPS15L1 [plasma membrane] (Mus musculus)

EPS15L1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001245304.1, NP_067058.1, NP_001245305.1, NP_001245303.1

OpenTargets

ENSG00000127527

HPA

ENSG00000127527-EPS15L1

GeneCards

Q9UBC2

Ensembl

ENSP00000471981, ENST00000597937, ENSG00000127527, ENST00000455140, ENSP00000248070, ENST00000535753, ENSP00000393313, ENSP00000472267, ENSP00000440103, ENST00000602022, ENST00000248070

PRO

Q9UBC2

Pharos - Targets

Q9UBC2

Orphanet

26524

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63218 GNG5	1	GNG5 [plasma membrane] (R-HSA-164383)	0.556	3
UniProt:P0DI81 TRAPPC2	1	TRAPPC2 [cytosol] (R-HSA-5683757)	0.556	3
UniProt:P61962 DCAF7	2	Unfolded DCAF7 [cytosol] (R-HSA-6813821) DCAF7 [nucleoplasm] (R-HSA-8863312)	0.508	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.508	2
UniProt:Q969G5 CAVN3			0.499	2

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