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OCRL [Golgi membrane]
Stable Identifier
R-HSA-434339
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Inositol polyphosphate 5-phosphatase OCRL-1, OCRL_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
Golgi Associated Vesicle Biogenesis (Homo sapiens)
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
OCRL [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
OCRL [Golgi membrane] (Homo sapiens)
trans-Golgi Network Coat Assembly (Homo sapiens)
Cargo:AP-1:Arf1-GTP:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
OCRL [Golgi membrane] (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
OCRL [Golgi membrane] (Homo sapiens)
trans-Golgi Network Vesicle Scission (Homo sapiens)
Cargo:AP-1:Beta-arrestin:Vamp:Clathrin Triskelion:Dynamin:Endophilin Complex [Golgi membrane] (Homo sapiens)
Cargo:AP-1:beta-Arrestin-1:Vamp Complex [Golgi membrane] (Homo sapiens)
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
OCRL [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01968 OCRL
Gene Names
OCRL, INPP5F, OCRL1
Chain
chain:1-901
Reference Genes
COSMIC (genes):INPP5F OCRL
COSMIC (genes):OCRL OCRL
dbSNP Gene:4952 OCRL
ENSEMBL:ENSG00000122126 OCRL
Participates
as a candidate of
Golgi-associated Vesicle Destined Cargo [Golgi membrane] (Homo sapiens)
Other forms of this molecule
OCRL [cytoplasmic vesicle membrane]
OCRL [plasma membrane]
OCRL [cytosol]
Inferred To
OCRL [Golgi membrane]
(Bos taurus)
OCRL [Golgi membrane]
(Canis familiaris)
OCRL [Golgi membrane]
(Gallus gallus)
OCRL [Golgi membrane]
(Sus scrofa)
Dd5P4 [Golgi membrane]
(Dictyostelium discoideum)
ocrl-1 [Golgi membrane]
(Caenorhabditis elegans)
Ocrl [Golgi membrane]
(Drosophila melanogaster)
Ocrl [Golgi membrane]
(Mus musculus)
Ocrl [Golgi membrane]
(Rattus norvegicus)
ocrl [Golgi membrane]
(Xenopus tropicalis)
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20340 RAB6A
8
RAB6A [endoplasmic reticulum membrane]
(R-HSA-8849253)
RAB6A [trans-Golgi network membrane]
(R-HSA-6810981)
GGC-RAB6A [trans-Golgi network membrane]
(R-HSA-8876079)
GGC-RAB6A [cytosol]
(R-HSA-8874052)
RAB6A [cytosol]
(R-HSA-6810979)
RAB6A [plasma membrane]
(R-HSA-6804981)
RAB6A [secretory granule membrane]
(R-HSA-6804970)
RAB6A [Golgi membrane]
(R-HSA-1604442)
0.875
14
UniProt:P20339 RAB5A
7
RAB5A [cytosol]
(R-HSA-2201187)
GGC-RAB5A [macropinosome membrane]
(R-HSA-9837697)
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [early endosome membrane]
(R-HSA-2130175)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
0.799
11
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.556
3
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.534
2
UniProt:Q9NYZ3 GTSE1
4
GTSE1 [cytosol]
(R-HSA-8852264)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
0.527
2
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.508
3
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