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OCRL [cytosol]
Stable Identifier
R-HSA-1806196
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Inositol polyphosphate 5-phosphatase OCRL-1, OCRL_HUMAN, OCRL1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)
INPP5(4) [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
INPP5(3)/ITPK1 [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the Golgi membrane (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane (Homo sapiens)
OCRL/INPP5E [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)
RAC3 GAPs [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)
RHOJ GAPs [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
OCRL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01968 OCRL
Gene Names
OCRL, INPP5F, OCRL1
Chain
chain:1-901
Reference Genes
COSMIC (genes):INPP5F OCRL
COSMIC (genes):OCRL OCRL
dbSNP Gene:4952 OCRL
ENSEMBL:ENSG00000122126 OCRL
Participates
as a candidate of
RHOJ GAPs [cytosol] (Homo sapiens)
RAC3 GAPs [cytosol] (Homo sapiens)
as a member of
INPP5(4) [cytosol] (Homo sapiens)
INPP5(3)/ITPK1 [cytosol] (Homo sapiens)
OCRL/INPP5E [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
Other forms of this molecule
OCRL [Golgi membrane]
OCRL [cytoplasmic vesicle membrane]
OCRL [plasma membrane]
Inferred To
OCRL [cytosol]
(Bos taurus)
OCRL [cytosol]
(Canis familiaris)
OCRL [cytosol]
(Gallus gallus)
OCRL [cytosol]
(Plasmodium falciparum)
OCRL [cytosol]
(Schizosaccharomyces pombe)
OCRL [cytosol]
(Sus scrofa)
Ocrl [cytosol]
(Drosophila melanogaster)
Ocrl [cytosol]
(Mus musculus)
Ocrl [cytosol]
(Rattus norvegicus)
ocrl-1 [cytosol]
(Caenorhabditis elegans)
Dd5P4 [cytosol]
(Dictyostelium discoideum)
ocrl [cytosol]
(Xenopus tropicalis)
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20340 RAB6A
8
RAB6A [endoplasmic reticulum membrane]
(R-HSA-8849253)
RAB6A [trans-Golgi network membrane]
(R-HSA-6810981)
GGC-RAB6A [trans-Golgi network membrane]
(R-HSA-8876079)
GGC-RAB6A [cytosol]
(R-HSA-8874052)
RAB6A [cytosol]
(R-HSA-6810979)
RAB6A [plasma membrane]
(R-HSA-6804981)
RAB6A [secretory granule membrane]
(R-HSA-6804970)
RAB6A [Golgi membrane]
(R-HSA-1604442)
0.875
14
UniProt:P20339 RAB5A
7
RAB5A [cytosol]
(R-HSA-2201187)
GGC-RAB5A [macropinosome membrane]
(R-HSA-9837697)
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [early endosome membrane]
(R-HSA-2130175)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
0.799
11
UniProt:P63000 RAC1
6
RAC1 [plasma membrane]
(R-HSA-351141)
RAC1 [cytosol]
(R-HSA-442615)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
0.556
3
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.534
2
UniProt:Q9NYZ3 GTSE1
4
GTSE1 [cytosol]
(R-HSA-8852264)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
0.527
2
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.508
3
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