Reactome | HIST2H2BE [extracellular region]

HIST2H2BE [extracellular region]

Stable Identifier

R-HSA-977571

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Histone H2B.q

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Serum amyloid P binds DNA and chromatin (Homo sapiens)
    - Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
      - Chromatin [extracellular region] (Homo sapiens)
        
        Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
        
        Histone H2B [extracellular region] (Homo sapiens)
        
        HIST2H2BE [extracellular region] (Homo sapiens)
    - Serum amyloid P-component pentamer:Double-stranded DNA [extracellular region] (Homo sapiens)
      - Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
        
        Chromatin [extracellular region] (Homo sapiens)
        
        Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
        
        Histone H2B [extracellular region] (Homo sapiens)
        
        HIST2H2BE [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16778 H2BC21

Gene Names

H2BC21, H2BFQ, HIST2H2BE

Chain

initiator methionine:, chain:2-126

Reference Genes

BioGPS Gene:8349 H2BC21

CTD Gene:8349 H2BC21

dbSNP Gene:8349 H2BC21

ENSEMBL:ENSG00000184678 HIST2H2BE

ENSEMBL_homo_sapiens_GENE:ENSG00000184678.11 H2BC21

HGNC:4760 H2BC21

KEGG Gene (Homo sapiens):8349 H2BC21

Monarch:8349 H2BC21

NCBI Gene:8349 H2BC21

OMIM:601831 H2BC21

UCSC:Q16778 H2BC21

Reference Transcript

RefSeq:NM_003528.2 H2BC21

Other Identifiers

11717090_a_at

16692632

202708_PM_s_at

202708_s_at

2357917

2434125

2434126

2434127

2434128

2459531

33352_at

7919625

7919637

8349

A_23_P149545

A_24_P148321

A_24_P156911

A_33_P3229246

GE59831

GO:0000786

GO:0002227

GO:0002376

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006334

GO:0019731

GO:0030527

GO:0042742

GO:0043226

GO:0043229

GO:0046982

GO:0050830

GO:0061844

GO:0065003

GO:0070062

GO:0098542

HMNXSV003010633

ILMN_1732071

PH_hs_0000289

TC01003193.hg

X57985_rna2_at

g4504276_3p_s_at

Participates

as a candidate of

Histone H2B [extracellular region] (Homo sapiens)

Other forms of this molecule

Ub-HIST2H2BE [nucleoplasm]

Ack-HIST2H2BE [nucleoplasm]

AcK13-HIST2H2BE [nucleoplasm]

AcK21-HIST2H2BE [nucleoplasm]

AcK6-HIST2H2BE [nucleoplasm]

AcK16-HIST2H2BE [nucleoplasm]

Ub-121-HIST2H2BE [nucleoplasm]

HIST2H2BE [nucleoplasm]

Cross References

RefSeq

NP_003519.1

OpenTargets

ENSG00000184678

HPA

ENSG00000184678-H2BC21

GeneCards

Q16778

Ensembl

ENST00000369155, ENSP00000358151, ENSG00000184678

PRO

Q16778

Pharos - Targets

Q16778

PDB

8EVI, 7BXT, 8UQ9, 8UQD, 8SPS, 7U0G, 6M4H, 8H1T, 8UQC, 8EVH, 8DK5, 8SYP, 8UQ8, 8UQB, 6M4G, 7U0J, 8EVG, 7EA8, 6KBB, 6A7U, 8UQE, 8EVJ, 6M4D, 4NFT, 7U0I, 8UQA, 8SPU

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.564	2
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.564	3
UniProt:P17096 HMGA1	2	HMGA1 [cytosol] (R-HSA-3004619) HMGA1 [nucleoplasm] (R-HSA-3004623)	0.564	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.556	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	2
UniProt:Q9UPP1 PHF8	1	PHF8 [nucleoplasm] (R-HSA-5423096)	0.527	2

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