Reactome | Ub-121-HIST2H2BE [nucleoplasm]

Ub-121-HIST2H2BE [nucleoplasm]

Stable Identifier

R-HSA-3364018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H2B.q K121ub

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
        
        MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST2H2BE [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16778 H2BC21

Gene Names

H2BC21, H2BFQ, HIST2H2BE

Chain

initiator methionine:, chain:2-126

Reference Genes

BioGPS Gene:8349 H2BC21

COSMIC (genes):HIST2H2BE H2BC21

CTD Gene:8349 H2BC21

dbSNP Gene:8349 H2BC21

ENSEMBL:ENSG00000184678 HIST2H2BE

HGNC:4760 H2BC21

KEGG:hsa:8349 H2BC21

Monarch:8349 H2BC21

NCBI Gene:8349 H2BC21

OMIM:601831 H2BC21

UCSC:Q16778 H2BC21

Reference Transcript

RefSeq:NM_003528.2 H2BC21

Other Identifiers

11717090_a_at

16692632

202708_PM_s_at

202708_s_at

2357917

2434125

2434126

2434127

2434128

2459531

33352_at

7919625

7919637

8349

A_23_P149545

A_24_P148321

A_24_P156911

A_33_P3229246

GE59831

GO:0000786

GO:0002227

GO:0002376

GO:0003677

GO:0005198

GO:0005515

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006334

GO:0019731

GO:0030527

GO:0042742

GO:0043226

GO:0043229

GO:0046982

GO:0050830

GO:0061844

GO:0065003

GO:0070062

GO:0098542

HMNXSV003010633

ILMN_1732071

PH_hs_0000289

TC01003193.hg

X57985_rna2_at

g4504276_3p_s_at

Participates

as a candidate of

Histone H2B K121ub [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HIST2H2BE [nucleoplasm]

AcK16-HIST2H2BE [nucleoplasm]

AcK6-HIST2H2BE [nucleoplasm]

AcK21-HIST2H2BE [nucleoplasm]

AcK13-HIST2H2BE [nucleoplasm]

HIST2H2BE [extracellular region]

Ack-HIST2H2BE [nucleoplasm]

Ub-HIST2H2BE [nucleoplasm]

Inferred To

H2Bv1 [nucleoplasm] (Dictyostelium discoideum)

H2B-VIII [nucleoplasm] (Gallus gallus)

His2B [nucleoplasm] (Drosophila melanogaster)

H2Bv2 [nucleoplasm] (Dictyostelium discoideum)

htb1 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of Ub-121-HIST1H2BB [nucleoplasm] (Gallus gallus)

Ub-121-HIST2H2BE [nucleoplasm] (Bos taurus)

Ub-121-HIST1H2BK [nucleoplasm] (Plasmodium falciparum)

h2bc11 [nucleoplasm] (Xenopus tropicalis)

H2B-V [nucleoplasm] (Gallus gallus)

H2Bv3 [nucleoplasm] (Dictyostelium discoideum)

H2B-VII [nucleoplasm] (Gallus gallus)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Plasmodium falciparum)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Saccharomyces cerevisiae)

hist2h2l [nucleoplasm] (Danio rerio)

HTB1 [nucleoplasm] (Saccharomyces cerevisiae)

HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

ubiquitinylated lysine at 121

Coordinate

121

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_003519.1

OpenTargets

ENSG00000184678

ENSEMBL

ENSP00000358151, ENST00000369155

HPA

ENSG00000184678-H2BC21

PRO

Q16778

Pharos - Targets

Q16778

GlyGen

Q16778

PDB

8UQA, 8UQB, 8UQC, 8EVI, 6M4H, 6M4G, 7BXT, 8UQD, 8UQ8, 8UQE, 6M4D, 8UQ9, 8SYP, 8H1T, 7U0J, 6KBB, 8EVJ, 8EVG, 8EVH, 7EA8, 6A7U, 8DK5, 7U0I, 7U0G, 8SPS, 8YJF, 8SPU, 4NFT

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.564	3
UniProt:P17096 HMGA1	2	HMGA1 [cytosol] (R-HSA-3004619) HMGA1 [nucleoplasm] (R-HSA-3004623)	0.564	2
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.564	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.556	3
UniProt:Q9UPP1 PHF8	1	PHF8 [nucleoplasm] (R-HSA-5423096)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	2

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