Reactome | Ub-121-HIST2H2BE [nucleoplasm]

Ub-121-HIST2H2BE [nucleoplasm]

Stable Identifier

R-HSA-3364018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H2B.q K121ub

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
        
        MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST2H2BE [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16778 H2BC21

Gene Names

H2BC21, H2BFQ, HIST2H2BE

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:8349 H2BC21

CTD Gene:8349 H2BC21

dbSNP Gene:8349 H2BC21

ENSEMBL:ENSG00000184678 HIST2H2BE

ENSEMBL:ENSG00000184678.11 H2BC21

HGNC:4760 H2BC21

KEGG Gene (Homo sapiens):8349 H2BC21

Monarch:8349 H2BC21

NCBI Gene:8349 H2BC21

OMIM:601831 H2BC21

UCSC:Q16778 H2BC21

Reference Transcript

RefSeq:NM_003528.2 H2BC21

Other Identifiers

11717090_a_at

16692632

202708_PM_s_at

202708_s_at

2357917

2434125

2434126

2434127

2434128

2459531

33352_at

7919625

7919637

8349

A_23_P149545

A_24_P148321

A_24_P156911

A_33_P3229246

GE59831

GO:0000786

GO:0002227

GO:0002376

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006334

GO:0019731

GO:0030527

GO:0042742

GO:0043226

GO:0043229

GO:0046982

GO:0050830

GO:0061844

GO:0065003

GO:0070062

GO:0098542

HMNXSV003010633

ILMN_1732071

PH_hs_0000289

TC01003193.hg

X57985_rna2_at

g4504276_3p_s_at

Participates

as a candidate of

Histone H2B K121ub [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-HIST2H2BE [nucleoplasm]

Ack-HIST2H2BE [nucleoplasm]

HIST2H2BE [extracellular region]

AcK13-HIST2H2BE [nucleoplasm]

AcK21-HIST2H2BE [nucleoplasm]

AcK6-HIST2H2BE [nucleoplasm]

AcK16-HIST2H2BE [nucleoplasm]

HIST2H2BE [nucleoplasm]

Inferred To

LOC100155267 [nucleoplasm] (Sus scrofa)

h2bc14 [nucleoplasm] (Xenopus tropicalis)

Homologues of Ub-121-HIST1H2BB [nucleoplasm] (Danio rerio)

Ub-121-HIST2H2BE [nucleoplasm] (Bos taurus)

Ub-121-HIST2H2BE [nucleoplasm] (Canis familiaris)

Ub-121-HIST1H2BK [nucleoplasm] (Danio rerio)

si:ch211-113a14.29 [nucleoplasm] (Danio rerio)

Modified Residues

Name

ubiquitinylated lysine at 121

Coordinate

121

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_003519.1

OpenTargets

ENSG00000184678

GeneCards

Q16778

HPA

ENSG00000184678-H2BC21

Ensembl

ENST00000369155, ENSP00000358151, ENSG00000184678

PRO

Q16778

Pharos - Targets

Q16778

PDB

4NFT, 6KBB, 7BXT, 6M4G, 6A7U, 6M4D, 8H1T, 7EA8, 6M4H

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.556	3