Reactome | AcK6-HIST1H2BL [nucleoplasm]

AcK6-HIST1H2BL [nucleoplasm]

Stable Identifier

R-HSA-4568719

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HATs acetylate histones (Homo sapiens)
    - EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
      - AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BL [nucleoplasm] (Homo sapiens)
        
        AcK6-HIST1H2BL [nucleoplasm] (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1/2 containing-complexes deacetylate histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BL [nucleoplasm] (Homo sapiens)
        
        AcK6-HIST1H2BL [nucleoplasm] (Homo sapiens)
    - HDAC10 deacetylates histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BL [nucleoplasm] (Homo sapiens)
        
        AcK6-HIST1H2BL [nucleoplasm] (Homo sapiens)
    - HDAC3 containing complexes deacetylate histone (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BL [nucleoplasm] (Homo sapiens)
        
        AcK6-HIST1H2BL [nucleoplasm] (Homo sapiens)
    - HDAC8 deacetylates histones (Homo sapiens)
      - Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-histone HIST1H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST1H2BL [nucleoplasm] (Homo sapiens)
        
        AcK6-HIST1H2BL [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99880 HIST1H2BL

Gene Names

HIST1H2BL, H2BFC

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:8340 HIST1H2BL

COSMIC (genes):HIST1H2BL HIST1H2BL

CTD Gene:8340 HIST1H2BL

dbSNP Gene:8340 HIST1H2BL

ENSEMBL:ENSG00000185130 HIST1H2BL

ENSEMBL_homo_sapiens_GENE:ENSG00000185130 HIST1H2BL

HGNC:4748 HIST1H2BL

KEGG Gene (Homo sapiens):8340 HIST1H2BL

Monarch:8340 HIST1H2BL

NCBI Gene:8340 HIST1H2BL

OMIM:602800 HIST1H2BL

UCSC:Q99880 HIST1H2BL

Reference Transcript

RefSeq:NM_003519.3 HIST1H2BL

Other Identifiers

0002260619

11740828_at

17016486

2947033

2947034

2947035

2947037

35576_f_at

36347_f_at

42205

43013

48671

8124510

8340

A_23_P8013

AAN06695

ADDON002867.hg

AF531295

AK312114

AL009179

BAG35050

BC093759

BC093761

CAB06035

CCDS4625

ENSG00000185130

ENSP00000366618

ENST00000377401

EntrezGene:8340

g5579460_3p_at

GE511997

GO:0000786

GO:0003674

GO:0003677

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006334

GO:0006464

GO:0008150

GO:0016567

GO:0022607

GO:0032991

GO:0043226

GO:0046982

GO:0051276

GO:0065003

GO:0070062

HGNC:4748

HIST1H2BL

HIST1H2BL-201

HPA042205

HPA043013

HPA048671

ILMN_1652998

IPR000558

IPR007125

IPR009072

MIM:602800

NM_003519

NP_003510

PF00125

PH_hs_0029201

PH_hs_0031779

PR00621

SM00427

TC06001421.hg

uc003njl.4

UPI0000001BD6

Z83740

Participant Of

hasMember

AcK(6,13,16,21)-HIST1H2BL [nucleoplasm]

Other forms of this molecule

HIST1H2BL [extracellular region]

Ub-HIST1H2BL [nucleoplasm]

AcK-HIST1H2BL [nucleoplasm]

AcK13-HIST1H2BL [nucleoplasm]

AcK16-HIST1H2BL [nucleoplasm]

AcK21-HIST1H2BL [nucleoplasm]

Ub-121-HIST1H2BL [nucleoplasm]

HIST1H2BL [nucleoplasm]

Inferred To

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Arabidopsis thaliana)

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Caenorhabditis elegans)

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Danio rerio)

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Gallus gallus)

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Oryza sativa)

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Plasmodium falciparum)

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Taeniopygia guttata)

Homologues of AcK6-HIST1H2BB [nucleoplasm] (Xenopus tropicalis)

AcK6-HIST1H2BB [nucleoplasm] (Arabidopsis thaliana)

AcK6-HIST1H2BB [nucleoplasm] (Caenorhabditis elegans)

AcK6-HIST1H2BB [nucleoplasm] (Danio rerio)

AcK6-HIST1H2BB [nucleoplasm] (Dictyostelium discoideum)

AcK6-HIST1H2BB [nucleoplasm] (Gallus gallus)

AcK6-HIST1H2BB [nucleoplasm] (Oryza sativa)

AcK6-HIST1H2BB [nucleoplasm] (Plasmodium falciparum)

AcK6-HIST1H2BB [nucleoplasm] (Saccharomyces cerevisiae)

AcK6-HIST1H2BB [nucleoplasm] (Schizosaccharomyces pombe)

AcK6-HIST1H2BB [nucleoplasm] (Taeniopygia guttata)

AcK6-HIST1H2BB [nucleoplasm] (Xenopus tropicalis)

AcK6-HIST1H2BL [nucleoplasm] (Bos taurus)

Modified Residues

Name

N6-acetyl-L-lysine at 6

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_003510.1

OpenTargets

ENSG00000185130

GeneCards

Q99880

PRO

Q99880

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CW1 AP2M1	6	AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [endolysosome membrane] (R-HSA-6784828) AP2M1 [lysosomal membrane] (R-HSA-196144) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.488	2