Reactome | AcK13-HIST2H2BE [nucleoplasm]

AcK13-HIST2H2BE [nucleoplasm]

Stable Identifier

R-HSA-4568651

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HCMV Infection (Homo sapiens)
      - HCMV Early Events (Homo sapiens)
        
        Activation of Latent HCMV Genome (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        Delayed Early (DE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        Immediate Early (IE) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        Transcriptional Activation of the HCMV Genome (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST2H2BE [nucleoplasm] (Homo sapiens)
      - HCMV Late Events (Homo sapiens)
        
        Late (L) Gene Expression (Homo sapiens)
        
        Transcriptionally Active HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Acetylated core histone octamer [nucleoplasm] (Homo sapiens)
        
        Acetylated histone H2A:H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)- histone H2B [nucleoplasm] (Homo sapiens)
        
        AcK(6,13,16,21)-HIST2H2BE [nucleoplasm] (Homo sapiens)
        
        AcK13-HIST2H2BE [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16778 H2BC21

Gene Names

H2BC21, H2BFQ, HIST2H2BE

Chain

initiator methionine:, chain:2-126

Reference Genes

BioGPS Gene:8349 H2BC21

COSMIC (genes):HIST2H2BE H2BC21

CTD Gene:8349 H2BC21

dbSNP Gene:8349 H2BC21

ENSEMBL:ENSG00000184678 HIST2H2BE

HGNC:4760 H2BC21

KEGG:hsa:8349 H2BC21

Monarch:8349 H2BC21

NCBI Gene:8349 H2BC21

OMIM:601831 H2BC21

UCSC:Q16778 H2BC21

Reference Transcript

RefSeq:NM_003528.2 H2BC21

Other Identifiers

11717090_a_at

16692632

202708_PM_s_at

202708_s_at

2357917

2434125

2434126

2434127

2434128

2459531

33352_at

7919625

7919637

8349

A_23_P149545

A_24_P148321

A_24_P156911

A_33_P3229246

GE59831

GO:0000786

GO:0002227

GO:0002376

GO:0003677

GO:0005198

GO:0005515

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006334

GO:0019731

GO:0030527

GO:0042742

GO:0043226

GO:0043229

GO:0046982

GO:0050830

GO:0061844

GO:0065003

GO:0070062

GO:0098542

HMNXSV003010633

ILMN_1732071

PH_hs_0000289

TC01003193.hg

X57985_rna2_at

g4504276_3p_s_at

Participates

as a candidate of

AcK13-replicative histone H2B [nucleoplasm] (Homo sapiens)

as a member of

AcK(6,13,16,21)-HIST2H2BE [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HIST2H2BE [nucleoplasm]

Ub-121-HIST2H2BE [nucleoplasm]

AcK16-HIST2H2BE [nucleoplasm]

AcK6-HIST2H2BE [nucleoplasm]

AcK21-HIST2H2BE [nucleoplasm]

HIST2H2BE [extracellular region]

Ack-HIST2H2BE [nucleoplasm]

Ub-HIST2H2BE [nucleoplasm]

Inferred To

H2Bv1 [nucleoplasm] (Dictyostelium discoideum)

H2B-VIII [nucleoplasm] (Gallus gallus)

His2B [nucleoplasm] (Drosophila melanogaster)

H2Bv2 [nucleoplasm] (Dictyostelium discoideum)

htb1 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Dictyostelium discoideum)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Gallus gallus)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Plasmodium falciparum)

Homologues of AcK13-HIST1H2BB [nucleoplasm] (Saccharomyces cerevisiae)

h2bc11 [nucleoplasm] (Xenopus tropicalis)

H2B-V [nucleoplasm] (Gallus gallus)

AcK13-HIST1H2BB [nucleoplasm] (Plasmodium falciparum)

H2BC21 [nucleoplasm] (Sus scrofa)

H2Bv3 [nucleoplasm] (Dictyostelium discoideum)

H2B-VII [nucleoplasm] (Gallus gallus)

hist2h2l [nucleoplasm] (Danio rerio)

HTB1 [nucleoplasm] (Saccharomyces cerevisiae)

AcK13-HIST2H2BE [nucleoplasm] (Bos taurus)

AcK13-HIST2H2BE [nucleoplasm] (Canis familiaris)

HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

N6-acetyl-L-lysine at 13

Coordinate

PsiMod Name

N6-acetyl-L-lysine [MOD:00064]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.

Cross References

RefSeq

NP_003519.1

OpenTargets

ENSG00000184678

ENSEMBL

ENSP00000358151, ENST00000369155

HPA

ENSG00000184678-H2BC21

PRO

Q16778

Pharos - Targets

Q16778

GlyGen

Q16778

PDB

8UQA, 8UQB, 8UQC, 8EVI, 6M4H, 6M4G, 7BXT, 8UQD, 8UQ8, 8UQE, 6M4D, 8UQ9, 8SYP, 8H1T, 7U0J, 6KBB, 8EVJ, 8EVG, 8EVH, 7EA8, 6A7U, 8DK5, 7U0I, 7U0G, 8SPS, 8YJF, 8SPU, 4NFT

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.564	3
UniProt:P17096 HMGA1	2	HMGA1 [cytosol] (R-HSA-3004619) HMGA1 [nucleoplasm] (R-HSA-3004623)	0.564	2
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.564	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.556	3
UniProt:Q9UPP1 PHF8	1	PHF8 [nucleoplasm] (R-HSA-5423096)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	2