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EPS15L1 [cytosol]
Stable Identifier
R-HSA-8935900
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Eps15R
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
EPS15L1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBC2 EPS15L1
Gene Names
EPS15L1, EPS15R
Chain
initiator methionine:, chain:2-864
Reference Genes
BioGPS Gene:58513 EPS15L1
COSMIC (genes):EPS15L1 EPS15L1
CTD Gene:58513 EPS15L1
dbSNP Gene:58513 EPS15L1
ENSEMBL:ENSG00000127527 EPS15L1
HGNC:24634 EPS15L1
KEGG:hsa:58513 EPS15L1
Monarch:58513 EPS15L1
NCBI Gene:58513 EPS15L1
UCSC:Q9UBC2 EPS15L1
Reference Transcript
RefSeq:NM_001258374.1 EPS15L1
RefSeq:NM_021235.2 EPS15L1
RefSeq:NM_001258375.1 EPS15L1
RefSeq:NM_001258376.1 EPS15L1
Other Identifiers
11729752_a_at
11746465_a_at
11759882_a_at
11760280_a_at
11760426_a_at
16869984
221056_PM_x_at
221056_x_at
222112_PM_at
222112_at
222113_PM_s_at
222113_s_at
231926_PM_at
231926_at
232438_PM_at
232438_at
239497_PM_at
239497_at
243482_PM_at
243482_at
3853815
3853816
3853824
3853825
3853826
3853827
3853828
3853832
3853834
3853835
3853837
3853838
3853841
3853842
3853843
3853846
3853847
3853848
3853849
3853850
3853851
3853852
3853853
3853863
3853865
3853866
3853868
3853870
3853871
3853877
3853878
3853879
3853881
3853882
3853883
3853884
3853885
3853886
3853888
3853891
3853892
3853893
3853894
3853895
3853896
3853905
3853906
3853907
3853908
3853917
3853921
53351_at
58513
59027_at
62047_at
74271_at
79358_at
8035120
85923_at
A_23_P38941
A_33_P3350828
GE53412
GO:0005509
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005905
GO:0006897
GO:0016020
GO:0016192
GO:0016197
GO:0030132
GO:0043226
GO:0045296
GO:0046872
HMNXSV003001360
HMNXSV003019275
HMNXSV003026878
HMNXSV003043582
Hs.117745.0.A1_3p_at
Hs.117745.0.A1_3p_x_at
Hs.147176.1.S1_3p_at
Hs.147176.2.S1_3p_at
Hs.192142.0.A1_3p_at
Hs.318510.0.S1_3p_at
ILMN_1708369
PH_hs_0008803
PH_hs_0038197
TC19001265.hg
g10864046_3p_a_at
Participates
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
EPS15L1 [plasma membrane]
Inferred To
Eps15l1 [cytosol]
(Rattus norvegicus)
Eps-15 [cytosol]
(Drosophila melanogaster)
ehs-1 [cytosol]
(Caenorhabditis elegans)
EPS15L1 [cytosol]
(Bos taurus)
EPS15L1 [cytosol]
(Canis familiaris)
EPS15L1 [cytosol]
(Gallus gallus)
EPS15L1 [cytosol]
(Mus musculus)
EPS15L1 [cytosol]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000127527
ENSEMBL
ENSG00000127527
,
ENST00000248070
,
ENSP00000472267
,
ENSP00000471981
,
ENSP00000248070
,
ENSP00000393313
,
ENSP00000440103
,
ENST00000535753
,
ENST00000597937
,
ENST00000455140
,
ENST00000602022
HPA
ENSG00000127527-EPS15L1
GeneCards
EPS15L1
PRO
Q9UBC2
Pharos - Targets
Q9UBC2
Orphanet
EPS15L1
GlyGen
Q9UBC2
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.738
5
UniProt:P53680 AP2S1
4
AP2S1 [endolysosome membrane]
(R-HSA-6784821)
AP2S1 [plasma membrane]
(R-HSA-389382)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130707)
AP2S1 [cytosol]
(R-HSA-182197)
0.643
4
UniProt:Q8WXE9 STON2
2
NEDD8-STON2 [cytosol]
(R-HSA-8863733)
STON2 [cytosol]
(R-HSA-8862856)
0.59
2
UniProt:Q9NZM3 ITSN2
1
ITSN2 [cytosol]
(R-HSA-8862264)
0.564
3
UniProt:P0DI81 TRAPPC2
1
TRAPPC2 [cytosol]
(R-HSA-5683757)
0.556
3
UniProt:P63218 GNG5
1
GNG5 [plasma membrane]
(R-HSA-164383)
0.556
3
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.527
4
UniProt:Q9HBM1 SPC25
1
SPC25 [cytosol]
(R-HSA-375307)
0.527
4
UniProt:Q01850 CDR2
0.527
2
UniProt:Q86X29 LSR
1
LSR [plasma membrane]
(R-HSA-8933138)
0.527
2
UniProt:P63010 AP2B1
4
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
0.527
3
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.527
3
UniProt:P53350 PLK1
4
PLK1 [cytosol]
(R-HSA-164603)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [nucleoplasm]
(R-HSA-156720)
0.508
2
UniProt:P61962 DCAF7
2
DCAF7 [nucleoplasm]
(R-HSA-8863312)
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
0.508
2
UniProt:Q969G5 CAVN3
0.499
2
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